Total synthesis of aristolactams via a one-pot suzuki-miyaura coupling/aldol condensation cascade reaction

被引：74

作者：

Kim, Joa Kyum ^{[1
]}

Kim, Young Ha ^{[1
]}

Nam, Ho Tae ^{[1
]}

Kim, Bum Tae ^{[1
]}

Heo, Jung-Nyoung ^{[1
]}

机构：

[1] Korea Res Inst Chem Technol, Ctr Med Chem, Taejon 305600, South Korea

来源：

ORGANIC LETTERS | 2008年 / 10卷 / 16期

关键词：

D O I：

10.1021/ol801291k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A direct one-pot synthesis of phenanthrene lactams, which employs a Suzuki-Miyaura coupling/aldol condensation cascade reaction of isoindolin-1-one with 2-formyl phenyl boronic acid, has been developed. The approach is used to efficiently produce a number of natural aristolactams, such as aristolactam BII (cepharanone B), aristolactam BIII, aristolactam FI (piperolactam A), N-methyl piperolactam A, and sauristolactam.

引用

页码：3543 / 3546

页数：4

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