Total Synthesis of Bongkrekic Acid via Sequential Suzuki-Miyaura Coupling Reactions

被引：24
|
作者：
Kanematsu, Makoto [1 ]
Shindo, Mitsuru [2 ]
Yoshida, Masahiro [1 ]
Shishido, Kozo [1 ]
机构：
[1] Univ Tokushima, Grad Sch Pharmaceut Sci, Tokushima 7708505, Japan
[2] Kyushu Univ, Inst Mat Chem & Engn, Kasuga, Fukuoka 8168580, Japan
来源：
SYNTHESIS-STUTTGART | 2009年 / 17期
关键词：
apoptosis; conjugated diene; Suzuki-Miyaura coupling; palladium; bongkrekic acid; MITOCHONDRIAL PERMEABILITY TRANSITION; (E)-1-ALKENYLBORONIC ESTERS; STEREOSPECIFIC SYNTHESIS; CATALYTIC AMOUNT; TRANSFORMATION; ALDEHYDES; APOPTOSIS; OXIDATION; REAGENTS; OLEFINS;
D O I：
10.1055/s-0029-1216928
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient total synthesis of (+)-bongkrekic acid, a potent apoptosis inhibitor, has been accomplished by employing a convergent strategy based on the Suzuki-Miyaura coupling of three fully functionalized segments.
引用
收藏
页码：2893 / 2904
页数：12
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