Total Synthesis of Bongkrekic Acid via Sequential Suzuki-Miyaura Coupling Reactions

被引：24

作者：

Kanematsu, Makoto ^{[1
]}

Shindo, Mitsuru ^{[2
]}

Yoshida, Masahiro ^{[1
]}

Shishido, Kozo ^{[1
]}

机构：

[1] Univ Tokushima, Grad Sch Pharmaceut Sci, Tokushima 7708505, Japan

[2] Kyushu Univ, Inst Mat Chem & Engn, Kasuga, Fukuoka 8168580, Japan

来源：

SYNTHESIS-STUTTGART | 2009年 / 17期

关键词：

apoptosis; conjugated diene; Suzuki-Miyaura coupling; palladium; bongkrekic acid; MITOCHONDRIAL PERMEABILITY TRANSITION; (E)-1-ALKENYLBORONIC ESTERS; STEREOSPECIFIC SYNTHESIS; CATALYTIC AMOUNT; TRANSFORMATION; ALDEHYDES; APOPTOSIS; OXIDATION; REAGENTS; OLEFINS;

D O I：

10.1055/s-0029-1216928

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient total synthesis of (+)-bongkrekic acid, a potent apoptosis inhibitor, has been accomplished by employing a convergent strategy based on the Suzuki-Miyaura coupling of three fully functionalized segments.

引用

页码：2893 / 2904

页数：12

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