A convenient one-pot access to phenanthridinones via Suzuki-Miyaura cross-coupling reaction

被引：14
|
作者：
Tanimoto, Kouichi [1 ]
Nakagawa, Naomichi [1 ]
Takeda, Kazutaka [1 ]
Kirihata, Mitsunori [1 ]
Tanimori, Shinji [1 ]
机构：
[1] Osaka Prefecture Univ, Grad Sch Life & Environm Sci, Dept Biosci & Informat, Naka Ku, Sakai, Osaka 5998531, Japan
来源：
TETRAHEDRON LETTERS | 2013年 / 54卷 / 28期
关键词：
Phenanthridinone; Suzuki-Miyaura cross-coupling reaction; One-pot reaction; Heterocyclic compounds; Palladium catalyst; RING; DERIVATIVES; INHIBITOR;
D O I：
10.1016/j.tetlet.2013.05.022
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A convenient one-step access to biologically important phenanthridinones 1 has been realized based upon Suzuki-Miyaura cross-coupling reaction. Reactions of 2-aminophenylboronic acid 2 with 2-halobenzoate 3 took place smoothly to afford substituted phenanthridinones 1 in excellent yields in the presence of palladium(II) acetate and 2-dicyclohexylphosphino-2',6'-dimethoxybiphenyl (SPhos) as precatalysts. A natural product phenaglydon lb was synthesized in one-pot manner from readily available starting materials in 95% yield. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3712 / 3714
页数：3
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