A metal-free tandem cycloaddition strategy for the synthesis of indolizines from pyridine derivatives and γ-bromo-crotonates under mild conditions

被引：6

作者：

Li, Yanqiu ^{[1
]}

Yang, Bingchuan ^{[1
]}

Sun, Yan ^{[1
]}

Wang, Huayi ^{[1
]}

Li, Huipeng ^{[1
]}

Fang, Shuai ^{[1
]}

Niu, Xiaoyi ^{[1
]}

Ma, Chen ^{[1
,2
]}

机构：

[1] Shandong Univ, Sch Chem & Chem Engn, Jinan 250100, Peoples R China

[2] Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

来源：

RSC ADVANCES | 2013年 / 3卷 / 44期

基金：

美国国家科学基金会;

关键词：

NITROGEN-BRIDGED HETEROCYCLES; ONE-POT SYNTHESIS; PRACTICAL SYNTHESIS; AZOMETHINE YLIDES; ENTRY; INHIBITORS; CONSTRUCTION; PRECURSORS; INDOLE;

D O I：

10.1039/c3ra43613f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A one-pot synthetic protocol involving 1,3-dipolar cycloaddition/deprotonation/elimination/oxidation for the construction of indolizines has been proposed from easily available pyridine derivatives and gamma-bromo-crotonates via a metal-free tandem process. A variety of indolizine derivatives were synthesized under mild conditions. Noteworthy features of this synthetic strategy are short reaction time, using air as oxidant and mild reaction conditions.

引用

页码：21418 / 21423

页数：6

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