Indole-to-Carbazole Strategy for the Synthesis of Substituted Carbazoles under Metal-Free Conditions

被引：119
|
作者：
Chen, Shanping [1 ]
Li, Yuxia [1 ]
Ni, Penghui [1 ]
Huang, Huawen [1 ]
Deng, Guo-Jun [1 ]
机构：
[1] Xiangtan Univ, Coll Chem, Key Lab Environm Friendly Chem & Applicat, Minist Educ, Xiangtan 411105, Peoples R China
来源：
ORGANIC LETTERS | 2016年 / 18卷 / 20期
基金：
中国国家自然科学基金;
关键词：
C-H ACTIVATION; ONE-POT SYNTHESIS; DOUBLE N-ARYLATION; DEAROMATIZATION REACTIONS; REGIOSELECTIVE SYNTHESIS; AMBIENT-TEMPERATURE; OPTICAL-PROPERTIES; BOND AMINATION; PRIMARY AMINES; ALKALOIDS;
D O I：
10.1021/acs.orglett.6b02762
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient indole-to-carbazole strategy has been developed under metal-free conditions. This carbazole formation was highly promoted by NH4I with high regioselectivity through formal [2 + 2 + 2] annulation of indoles, ketones, and nitroolefins. It thus conveniently enabled the assembly of a large number of diversified carbazole products with good tolerance of a broad range of functional groups.
引用
收藏
页码：5384 / 5387
页数：4
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