Metal-free synthesis of highly substituted quinolines under mild conditions

被引：9

作者：

Natarajan, Rakesh ^{[1
]}

Unnikrishnan, Peruparambil A. ^{[1
]}

Radhamani, Sandhya ^{[2
]}

Rappai, John P. ^{[3
]}

Prathapan, Sreedharan ^{[1
]}

机构：

[1] Cochin Univ Sci & Technol, Dept Appl Chem, Kochi 682022, Kerala, India

[2] NSS Coll, Dept Chem, Ottapalam 679103, Palakkad, India

[3] Govt Victoria Coll, Dept Chem, Palakkad 678001, India

来源：

TETRAHEDRON LETTERS | 2016年 / 57卷 / 27-28期

关键词：

Nitrones; Quinolines; Electron deficient acetylenes; Fluorenone; 1,3-Dloplar addition; POLYSUBSTITUTED QUINOLINES; CATALYZED SYNTHESIS; ALCOHOLS; QUINAZOLINE; KETONES;

D O I：

10.1016/j.tetlet.2016.05.091

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Starting from easily accessible nitrones and acetylenes, a simple, metal free synthesis of substituted quinolines under mild conditions with high atom efficiency has been developed. Our method is flexible enough to introduce substituents regiospecifically at the 2,3,4,6,8-positions of the quinoline product. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：2981 / 2984

页数：4

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