PEG-400 as a carbon synthon: highly selective synthesis of quinolines and methylquinolines under metal-free conditions

被引：18

作者：

Ding, Chengcheng ^{[1
]}

Li, Shichen ^{[1
]}

Feng, Kaili ^{[1
]}

Ma, Chen ^{[1
]}

机构：

[1] Shandong Univ, Inst Organ Chem, Sch Chem & Chem Engn, Jinan 250100, Peoples R China

来源：

GREEN CHEMISTRY | 2021年 / 23卷 / 15期

基金：

美国国家科学基金会;

关键词：

ONE-POT SYNTHESIS; QUINOXALINE DERIVATIVES; EFFICIENT SYNTHESIS; IN-VITRO; POLYSUBSTITUTED QUINOLINES; BIOLOGICAL EVALUATION; DIMETHYL-SULFOXIDE; BRONSTED ACID; CYCLIZATION; ANNULATION;

D O I：

10.1039/d1gc01617b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A metal-free, peroxide-free, and efficient procedure for the highly selective synthesis of quinolines and methylquinolines was reported. The main feature of this method was that the same substrate can produce quinolines and methylquinolines, respectively, under different reaction conditions. PEG-400 was used as both a reactant and solvent in this reaction. The utility of the designed procedure was also demonstrated by the derivatization of the products to bioactive compounds.

引用

页码：5542 / 5548

页数：7

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