Indole-to-Carbazole Strategy for the Synthesis of Substituted Carbazoles under Metal-Free Conditions

被引：119

作者：

Chen, Shanping ^{[1
]}

Li, Yuxia ^{[1
]}

Ni, Penghui ^{[1
]}

Huang, Huawen ^{[1
]}

Deng, Guo-Jun ^{[1
]}

机构：

[1] Xiangtan Univ, Coll Chem, Key Lab Environm Friendly Chem & Applicat, Minist Educ, Xiangtan 411105, Peoples R China

来源：

ORGANIC LETTERS | 2016年 / 18卷 / 20期

基金：

中国国家自然科学基金;

关键词：

C-H ACTIVATION; ONE-POT SYNTHESIS; DOUBLE N-ARYLATION; DEAROMATIZATION REACTIONS; REGIOSELECTIVE SYNTHESIS; AMBIENT-TEMPERATURE; OPTICAL-PROPERTIES; BOND AMINATION; PRIMARY AMINES; ALKALOIDS;

D O I：

10.1021/acs.orglett.6b02762

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient indole-to-carbazole strategy has been developed under metal-free conditions. This carbazole formation was highly promoted by NH4I with high regioselectivity through formal [2 + 2 + 2] annulation of indoles, ketones, and nitroolefins. It thus conveniently enabled the assembly of a large number of diversified carbazole products with good tolerance of a broad range of functional groups.

引用

页码：5384 / 5387

页数：4

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