A metal-free tandem cycloaddition strategy for the synthesis of indolizines from pyridine derivatives and γ-bromo-crotonates under mild conditions

被引：6
|
作者：
Li, Yanqiu [1 ]
Yang, Bingchuan [1 ]
Sun, Yan [1 ]
Wang, Huayi [1 ]
Li, Huipeng [1 ]
Fang, Shuai [1 ]
Niu, Xiaoyi [1 ]
Ma, Chen [1 ,2 ]
机构：
[1] Shandong Univ, Sch Chem & Chem Engn, Jinan 250100, Peoples R China
[2] Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
来源：
RSC ADVANCES | 2013年 / 3卷 / 44期
基金：
美国国家科学基金会;
关键词：
NITROGEN-BRIDGED HETEROCYCLES; ONE-POT SYNTHESIS; PRACTICAL SYNTHESIS; AZOMETHINE YLIDES; ENTRY; INHIBITORS; CONSTRUCTION; PRECURSORS; INDOLE;
D O I：
10.1039/c3ra43613f
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A one-pot synthetic protocol involving 1,3-dipolar cycloaddition/deprotonation/elimination/oxidation for the construction of indolizines has been proposed from easily available pyridine derivatives and gamma-bromo-crotonates via a metal-free tandem process. A variety of indolizine derivatives were synthesized under mild conditions. Noteworthy features of this synthetic strategy are short reaction time, using air as oxidant and mild reaction conditions.
引用
收藏
页码：21418 / 21423
页数：6
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