One-Pot Three-Component Approach to the Synthesis of Polyfunctional Pyrazoles

被引：100

作者：

Zhang, Guolin ^{[1
]}

Ni, Hangcheng ^{[1
]}

Chen, Wenteng ^{[1
]}

Shao, Jiaan ^{[1
]}

Liu, Huan ^{[1
]}

Chen, Binhui ^{[1
]}

Yu, Yongping ^{[1
]}

机构：

[1] Zhejiang Univ, Zhejiang Prov Key Lab Anticanc Drug Res, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 23期

基金：

中国国家自然科学基金;

关键词：

VINYL AZIDES; CATALYZED SYNTHESIS; PYRROLES; FACILE; DERIVATIVES; INHIBITORS;

D O I：

10.1021/ol402810f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple, multicomponent, and straightforward reaction of vinyl azide, aldehyde, and tosylhydrazine affords the construction of 3,4,5-trisubstituted 1H-pyrazoles regioselectively in the presence of base with moderate to excellent yields. A range of functionality could be tolerated in this methodology, and a possible mechanism is proposed.

引用

页码：5967 / 5969

页数：3

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