One-Pot Three-Component Approach to the Synthesis of Polyfunctional Pyrazoles

被引：99
|
作者：
Zhang, Guolin [1 ]
Ni, Hangcheng [1 ]
Chen, Wenteng [1 ]
Shao, Jiaan [1 ]
Liu, Huan [1 ]
Chen, Binhui [1 ]
Yu, Yongping [1 ]
机构：
[1] Zhejiang Univ, Zhejiang Prov Key Lab Anticanc Drug Res, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China
来源：
ORGANIC LETTERS | 2013年 / 15卷 / 23期
基金：
中国国家自然科学基金;
关键词：
VINYL AZIDES; CATALYZED SYNTHESIS; PYRROLES; FACILE; DERIVATIVES; INHIBITORS;
D O I：
10.1021/ol402810f
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple, multicomponent, and straightforward reaction of vinyl azide, aldehyde, and tosylhydrazine affords the construction of 3,4,5-trisubstituted 1H-pyrazoles regioselectively in the presence of base with moderate to excellent yields. A range of functionality could be tolerated in this methodology, and a possible mechanism is proposed.
引用
收藏
页码：5967 / 5969
页数：3
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