Disturbances in humoral and cell-mediated immunity in rats with experimental depressive syndrome induced by systemic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

被引：0
|
作者：
Davydova, TV
Fomina, VG
Krupina, NA
Kryzhanovskii, GN
Evseev, VA
Orlova, IN
Iordanskaya, TE
机构：
[1] RUSSIAN ACAD SCI,LAB NEUROIMMUNOPATHOL,MOSCOW 117901,RUSSIA
[2] RUSSIAN ACAD SCI,INST GEN PATHOL & PATHOPHYSIOL,LAB GEN PATHOL NERVOUS SYST,MOSCOW 117901,RUSSIA
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 1997年 / 123卷 / 03期
基金：
俄罗斯基础研究基金会;
关键词：
depressive syndrome; MPTP; rats; T and B cells; immune complexes;
D O I：
10.1007/BF02445422
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Changes in humoral and cell-mediated immunity are studied in rats with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced depressive syndrome. A decrease in the lymphocyte count and in absolute and relative T cell counts and absolute B cell counts in peripheral blood and an increase in serum concentration of circulating immune complexes (CIC) are demonstrated. Serum CIC content increases, while the relative count of peripheral blood T cells remains decreased two weeks after discontinuation of MPTP and normalization of rats' behavior. Serum CIC content decreases and T cell count normalizes one month after discontinuation of MPTP.
引用
收藏
页码：267 / 270
页数：4
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