Disturbances in humoral and cell-mediated immunity in rats with experimental depressive syndrome induced by systemic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

被引：0

作者：

Davydova, TV

Fomina, VG

Krupina, NA

Kryzhanovskii, GN

Evseev, VA

Orlova, IN

Iordanskaya, TE

机构：

[1] RUSSIAN ACAD SCI,LAB NEUROIMMUNOPATHOL,MOSCOW 117901,RUSSIA

[2] RUSSIAN ACAD SCI,INST GEN PATHOL & PATHOPHYSIOL,LAB GEN PATHOL NERVOUS SYST,MOSCOW 117901,RUSSIA

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 1997年 / 123卷 / 03期

基金：

俄罗斯基础研究基金会;

关键词：

depressive syndrome; MPTP; rats; T and B cells; immune complexes;

D O I：

10.1007/BF02445422

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Changes in humoral and cell-mediated immunity are studied in rats with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced depressive syndrome. A decrease in the lymphocyte count and in absolute and relative T cell counts and absolute B cell counts in peripheral blood and an increase in serum concentration of circulating immune complexes (CIC) are demonstrated. Serum CIC content increases, while the relative count of peripheral blood T cells remains decreased two weeks after discontinuation of MPTP and normalization of rats' behavior. Serum CIC content decreases and T cell count normalizes one month after discontinuation of MPTP.

引用

页码：267 / 270

页数：4

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