Disturbances in humoral and cell-mediated immunity in rats with experimental depressive syndrome induced by systemic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

Changes in humoral and cell-mediated immunity are studied in rats with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced depressive syndrome. A decrease in the lymphocyte count and in absolute and relative T cell counts and absolute B cell counts in peripheral blood and an increase in serum concentration of circulating immune complexes (CIC) are demonstrated. Serum CIC content increases, while the relative count of peripheral blood T cells remains decreased two weeks after discontinuation of MPTP and normalization of rats' behavior. Serum CIC content decreases and T cell count normalizes one month after discontinuation of MPTP.