Synthesis and anti-inflammatory activity of indole glucosinolates

被引：41

作者：

Vo, Quan V. ^{[1
]}

Trenerry, Craige ^{[2
]}

Rochfort, Simone ^{[3
,4
]}

Wadeson, Jenny ^{[3
]}

Leyton, Carolina ^{[3
]}

Hughes, Andrew B. ^{[1
]}

机构：

[1] La Trobe Univ, Dept Chem, Bundoora, Vic 3086, Australia

[2] Knoxfield Ctr, Dept Primary Ind, Knoxfield 3180, Australia

[3] Victorian AgriBiosci Ctr, Dept Primary Ind, Bundoora, Vic 3083, Australia

[4] La Trobe Univ, Bundoora, Vic 3086, Australia

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2014年 / 22卷 / 02期

关键词：

Indole glucosinolates; Anti-inflammatory; Brassica; TNF-alpha; Glucobrassicin; 1-METHOXYINDOLES; CHEMISTRY;

D O I：

10.1016/j.bmc.2013.12.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The nitronate and nitrovinyl methods to synthesize indole glucosinolates (GLs) have been investigated. The results were applied to generally the most prevalent natural indole glucosinolates to synthesize 4-methoxyglucobrassicin (MGB) and neo-glucobrassicin (NGB) in moderate overall yield for the first time. The anti-inflammatory activity of the synthetic indole GLs was determined by inhibition of TNF-alpha secretion in LPS-stimulated THP-1 cells. The data showed that glucobrassicin (GB) exhibited higher activity than other synthetic indolyl GLs. (C) 2013 Elsevier Ltd. All rights reserved.

引用

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页码：856 / 864

页数：9

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