Design, synthesis, and preclinical evaluation of 7-benzyl -N-substituted phenyl-5H-pyrrolo[3,2-d]pyrimidin-4-amines as single agents with antitubulin and antiangiogenic activity as antitumor agents

被引：0

作者：

Gangjee, Aleem ^{[1
]}

Pavana, Roheeth Kumar ^{[1
]}

Ihnat, Michael A. ^{[2
]}

Hamel, Ernest ^{[3
]}

机构：

[1] Duquesne Univ, Grad Sch Pharmaceut Sci, Div Med Chem, Pittsburgh, PA 15282 USA

[2] Univ Oklahoma, Hlth Sci Ctr, Coll Pharm, Dept Pharmaceut Sci, Oklahoma City, OK 73117 USA

[3] NCI, Screening Technol Branch, Dev Therapeut Program, Div Canc Treatment & Diag,Frederick Natl Lab Canc, Frederick, MD 21702 USA

来源：

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 2012年 / 244卷

关键词：

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

321-MEDI

引用

页数：1

共 36 条

[1] Discovery and preclinical evaluation of 7-benzyl-N-(substituted)-pyrrolo [3,2-d]pyrimidin-4-amines as single agents with microtubule targeting effects along with triple -acting angiokinase inhibition as antitumor agents
Pavana, Roheeth Kumar
Choudhary, Shruti
Bastian, Anja
Ihnat, Michael A.
Bai, Ruoli
Hamel, Ernest
Gangjee, Aleem
BIOORGANIC & MEDICINAL CHEMISTRY, 2017, 25 (02) : 545 - 556
[2] 7-Benzyl-2-methyl-N-substituted-phenyl-5H-pyrrolo[3,2-d]pyrimidin-4-amines: Design, synthesis and evaluation as receptor tyrosine kinase inhibitors
Pavana, Roheeth Kumar
Gangjee, Aleem
Ihnat, Michael A.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2011, 241
[3] Novel Water-Soluble Substituted Pyrrolo[3,2-d]pyrimidines: Design, Synthesis, and Biological Evaluation as Antitubulin Antitumor Agents
Aleem Gangjee
Roheeth K. Pavana
Wei Li
Ernest Hamel
Cara Westbrook
Susan L. Mooberry
Pharmaceutical Research, 2012, 29 : 3033 - 3039
[4] Novel Water-Soluble Substituted Pyrrolo[3,2-d]pyrimidines: Design, Synthesis, and Biological Evaluation as Antitubulin Antitumor Agents
Gangjee, Aleem
Pavana, Roheeth K.
Li, Wei
Hamel, Ernest
Westbrook, Cara
Mooberry, Susan L.
PHARMACEUTICAL RESEARCH, 2012, 29 (11) : 3033 - 3039
[5] Design, synthesis and biological evaluation of novel, conformationally restricted, water soluble, substituted pyrrolo[3,2-d]pyrimidines as antitubulin antitumor agents
Pavana, Roheeth K.
Gangjee, Aleem
Hamel, Ernest
Mooberry, Susan L.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2011, 242
[6] Steric induced conformational restriction: Design, synthesis, and biological evaluation of novel pyrrolo[3,2-d] pyrimidines as water soluble antitubulin agents with antiangiogenic and antitumor potential
Gangjee, Aleem
Pavana, Roheeth Kumar
Gentile, Taylor
Bai, Rouli
Hamel, Ernest
Ihnat, Michael A.
Risinger, April L.
Mooberry, Susan L.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2013, 246
[7] Design, synthesis and biological evaluation of novel 6-substituted pyrrolo [3,2-d] pyrimidine analogues as antifolate antitumor agents
Tian, Chao
Wang, Meng
Han, Zifei
Fang, Fang
Zhang, Zhili
Wang, Xiaowei
Liu, Junyi
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 138 : 630 - 643
[8] Design and synthesis of 7-(3,4,5-trimethoxybenzyl)-N4-substituted phenyl-5H-pyrrolo[3,2-d] pyrimidine-2,4-diamines as receptor tyrosine kinase inhibitors
Gangjee, Aleem
Pavana, Roheeth K.
Ihnat, Michael A.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2009, 238
[9] Synthesis of novel 7-substituted pyrido[2′,3′:4,5]furo[3,2-d]pyrimidin-4-amines and their N-aryl analogues and evaluation of their inhibitory activity against Ser/Thr kinases
Deau, Emmanuel
Loidreau, Yvonnick
Marchand, Pascal
Nourrisson, Marie-Rene
Loaec, Nadege
Meijer, Laurent
Levacher, Vincent
Besson, Thierry
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2013, 23 (24) : 6784 - 6788
[10] Design, synthesis, and biological evaluation of 7-benzyl-4-alkyl-5-substituted-7H-pyrrolo[2,3-d]pyrimidin-2-amines as potential antimitotic agents that also reverse tumor resistance
Gangjee, Aleem
Zhao, Sai
Namjoshi, Ojas
Smith, Charles D.
Hamel, Ernest
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2013, 245

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