Design, synthesis, and biological evaluation of 7-benzyl-4-alkyl-5-substituted-7H-pyrrolo[2,3-d]pyrimidin-2-amines as potential antimitotic agents that also reverse tumor resistance

被引：0
|
作者：
Gangjee, Aleem [1 ]
Zhao, Sai [1 ]
Namjoshi, Ojas [1 ]
Smith, Charles D. [2 ]
Hamel, Ernest [3 ]
机构：
[1] Duquesne Univ, Dept Med Chem, Pittsburgh, PA 15282 USA
[2] Med Univ S Carolina, Dept Pharmaceut Sci, Charleston, SC 29425 USA
[3] NCI, Div Canc Treatment & Diag, Frederick, MD 21702 USA
来源：
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 2013年 / 245卷
关键词：
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
304-MEDI
引用
收藏
页数：1
相关论文
共 50 条
  • [1] 2-Amino-4-methyl-5-phenylethyl substituted-7-N-benzyl-pyrrolo[2,3-d]pyrimidines as novel antitumor antimitotic agents that also reverse tumor resistance
    Gangjee, Aleem
    Namjoshi, Ojas A.
    Keller, Staci N.
    Smith, Charles D.
    BIOORGANIC & MEDICINAL CHEMISTRY, 2011, 19 (14) : 4355 - 4365
  • [2] Synthesis of 5,7-disubstituted-4-methyl-7H-pyrrolo[2,3-d]pyrimidin-2-amines as microtubule inhibitors
    Gangjee, Aleem
    Kurup, Sonali
    Smith, Charles D.
    BIOORGANIC & MEDICINAL CHEMISTRY, 2013, 21 (05) : 1180 - 1189
  • [3] Synthesis and optimization of substituted furo[2,3-d]-pyrimidin-4-amines and 7H-pyrrolo[2,3-d]pyrimidin-4-amines as ACK1 inhibitors
    Jiao, XianYun
    Kopecky, David J.
    Liu, JinSong
    Liu, JinQian
    Jaen, Juan C.
    Cardozo, Mario G.
    Sharma, Rajiv
    Walker, Nigel
    Wesche, Holger
    Li, Shyun
    Farrelly, Ellyn
    Xiao, Shou-Hua
    Wang, Zhulun
    Kayser, Frank
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 22 (19) : 6212 - 6217
  • [4] Synthesis and evaluation of substituted pyrrolo[2,3-d]pyrimidines as antitumor antimitotics that also reverse tumor resistance
    Gangjee, Aleem
    Namjoshi, Ojas
    Zhao, Ying
    Smith, Charles D.
    DRUGS OF THE FUTURE, 2007, 32 : 36 - 36
  • [5] Design, synthesis and biological evaluation of 2-desamino-4-alkyl-5-[(substituted phenyl) ethyl]-7-substituted pyrrolo[2,3-d]pyrimidines as antitumor antimitoic agents
    Gangjee, Aleem
    Zhao, Sal
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2009, 237
  • [6] MEDI 74-Synthesis of 7-substituted benzyl-5-[(3,4,5-trimethoxyphenyl)ethyl]-4-methyl-7H-pyrrolo[2, 3-d]pyrimidin-2-amines as microtubule inhibitors
    Gangjee, Aleem
    Kurup, Sonali
    Smith, Charles D.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2008, 235
  • [7] PHOSPHORUS PENTOXIDE IN ORGANIC-SYNTHESIS .38. SYNTHESIS OF N-ARYL-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINES AND 7-ARYL-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINES FROM 3,7-DIHYDRO-2,5-DIMETHYL-4H-PYRROLO[2,3-D]PYRIMIDIN-4-ONE
    JORGENSEN, A
    FINLANDER, P
    PEDERSEN, EB
    CHEMICA SCRIPTA, 1988, 28 (04): : 427 - 429
  • [8] Discovery of 4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-amines as potent, selective and orally bioavailable LRRK2 inhibitors
    Ding, Xiao
    Stasi, Luigi Piero
    Ho, Ming-Hsun
    Zhao, Baowei
    Wang, Hailong
    Long, Kai
    Xu, Qiongfeng
    Sang, Yingxia
    Sun, Changhui
    Hu, Huan
    Yu, Haihua
    Wan, Zehong
    Wang, Lizhen
    Edge, Colin
    Liu, Qian
    Li, Yi
    Dong, Kelly
    Guan, Xiaoming
    Tattersall, F. David
    Reith, Alastair D.
    Ren, Feng
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 28 (09) : 1615 - 1620
  • [9] 7-Deazaadenines: synthesis of some new pyrrolo[2,3-d]pyrimidin-4-amines
    Davoodnia, Abolghasem
    Khashi, Maryam
    Tavakoli-Hoseini, Niloofar
    Moloudi, Raheleh
    Zamani, Hassan Ali
    MONATSHEFTE FUR CHEMIE, 2013, 144 (05): : 677 - 680
  • [10] 7-Deazaadenines: synthesis of some new pyrrolo[2,3-d]pyrimidin-4-amines
    Abolghasem Davoodnia
    Maryam Khashi
    Niloofar Tavakoli-Hoseini
    Raheleh Moloudi
    Hassan Ali Zamani
    Monatshefte für Chemie - Chemical Monthly, 2013, 144 : 677 - 680
12345