Design, synthesis, and biological evaluation of 7-benzyl-4-alkyl-5-substituted-7H-pyrrolo[2,3-d]pyrimidin-2-amines as potential antimitotic agents that also reverse tumor resistance

被引:0
|
作者
Gangjee, Aleem [1 ]
Zhao, Sai [1 ]
Namjoshi, Ojas [1 ]
Smith, Charles D. [2 ]
Hamel, Ernest [3 ]
机构
[1] Duquesne Univ, Dept Med Chem, Pittsburgh, PA 15282 USA
[2] Med Univ S Carolina, Dept Pharmaceut Sci, Charleston, SC 29425 USA
[3] NCI, Div Canc Treatment & Diag, Frederick, MD 21702 USA
关键词
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
304-MEDI
引用
收藏
页数:1
相关论文
共 50 条
  • [21] Design, synthesis and biological evaluation of pyrido[2,3-d]pyrimidin-7-(8H)-ones as HCV inhibitors
    Camarasa, Marta
    Puig de la Bellacasa, Raimon
    Gonzalez, Alex L.
    Ondono, Raul
    Estrada, Roger
    Franco, Sandra
    Badia, Roger
    Este, Jose
    Angel Martinez, Miguel
    Teixido, Jordi
    Clotet, Bonaventura
    Borrell, Jose I.
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2016, 115 : 463 - 483
  • [22] One-pot synthesis of 5-methyl-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one
    Kanamarlapudi, Ramanaiah C.
    Bednarz, Mark
    Wu, Wenxue
    Keyes, Philip
    ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2007, 11 (01) : 86 - 89
  • [23] PHOSPHORUS PENTOXIDE IN ORGANIC-SYNTHESIS .36. SYNTHESIS OF 7H-PYRROLO[2,3-D]PYRIMIDIN-2,4-DIAMINES AND 7-DEAZAISOGUANINES FROM 7H-PYRROLO[2,3-D]PYRIMIDIN-2,4-DIONES
    JORGENSEN, A
    MOHARRAM, HH
    PEDERSEN, EB
    CHEMICA SCRIPTA, 1988, 28 (02): : 201 - 204
  • [24] An improved synthesis of 4-chloro-7H-pyrrolo[2,3-d]pyrimidine
    Zhang, Yu-Liu
    Xu, Cheng-Tao
    Liu, Ting
    Zhu, Yong
    Luo, Yu
    CHEMISTRY OF HETEROCYCLIC COMPOUNDS, 2018, 54 (06) : 638 - 642
  • [25] An improved synthesis of 4-chloro-7H-pyrrolo[2,3-d]pyrimidine
    Yu-Liu Zhang
    Cheng-Tao Xu
    Ting Liu
    Yong Zhu
    Yu Luo
    Chemistry of Heterocyclic Compounds, 2018, 54 : 638 - 642
  • [26] Design, synthesis, and preclinical evaluation of 7-benzyl -N-substituted phenyl-5H-pyrrolo[3,2-d]pyrimidin-4-amines as single agents with antitubulin and antiangiogenic activity as antitumor agents
    Gangjee, Aleem
    Pavana, Roheeth Kumar
    Ihnat, Michael A.
    Hamel, Ernest
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2012, 244
  • [27] Design, synthesis and biological activity of N4-phenylsubstituted-7H-pyrrolo[2,3-d]pyrimidin-4-amines as dual inhibitors of aurora kinase A and epidermal growth factor receptor kinase
    Kurup, Sonali
    McAllister, Bradley
    Liskova, Pavlina
    Mistry, Trusha
    Fanizza, Anthony
    Stanford, Dan
    Slawska, Jolanta
    Keller, Ulrich
    Hoellein, Alexander
    JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2017, 33 (01) : 74 - 84
  • [28] Design, synthesis and biological evaluation of 6-substituted pyrrolo[2,3-d]pyrimidines as dual inhibitors of TS and AICARFTase and as potential antitumor agents
    Liu, Yi
    Li, Meng
    Zhang, Hongying
    Yuan, Jiangsong
    Zhang, Congying
    Zhang, Kai
    Guo, Huicai
    Zhao, Lijuan
    Du, Yumin
    Wang, Lei
    Ren, Leiming
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2016, 115 : 245 - 256
  • [29] Design, synthesis, and biological evaluation of substituted furo[2,3-d]pyrimidines as potent antimitotic agents that circumvent Pgp and bIII-tubulin mediated resistance
    Gangjee, Aleem
    Devambatla, Ravi Kumar Vyas
    Choudhary, Shruti
    Bai, Ruoli
    Hamel, Ernest
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2012, 244
  • [30] Design, Synthesis, and biological evaluation of 7H-Pyrrolo[2,3-d] pyrimidines as potent HPK1 kinase inhibitors
    Wu, Feifei
    Li, Huiyu
    Li, Weiqiang
    Zhang, Laishun
    An, Qi
    Sun, Jiaqi
    Zhang, Qian
    Sun, Yaoliang
    Xu, Lei
    Yu, Jinghua
    Diao, Xingxing
    Li, Jia
    Meng, Linghua
    Xu, Shilin
    BIOORGANIC & MEDICINAL CHEMISTRY, 2025, 119