Design, synthesis, and biological evaluation of 7-benzyl-4-alkyl-5-substituted-7H-pyrrolo[2,3-d]pyrimidin-2-amines as potential antimitotic agents that also reverse tumor resistance

被引：0

作者：

Gangjee, Aleem ^{[1
]}

Zhao, Sai ^{[1
]}

Namjoshi, Ojas ^{[1
]}

Smith, Charles D. ^{[2
]}

Hamel, Ernest ^{[3
]}

机构：

[1] Duquesne Univ, Dept Med Chem, Pittsburgh, PA 15282 USA

[2] Med Univ S Carolina, Dept Pharmaceut Sci, Charleston, SC 29425 USA

[3] NCI, Div Canc Treatment & Diag, Frederick, MD 21702 USA

来源：

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 2013年 / 245卷

关键词：

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

304-MEDI

引用

页数：1

共 50 条

[31] Design, synthesis and biological evaluation of 7H-pyrrolo[2,3-d] pyrimidin-4-amine derivatives as selective Btk inhibitors with improved pharmacokinetic properties for the treatment of rheumatoid arthritis
He, Linhong
Pei, Heying
Zhang, Chufeng
Shao, Mingfeng
Li, Dan
Tang, Mingli
Wang, Taijing
Chen, Xiaoxin
Xiang, Mingli
Chen, Lijuan
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 145 : 96 - 112
[32] Design, synthesis and biological evaluation of 7-((7H-pyrrolo[2,3-d] pyrimidin-4-yl)oxy)-2,3-dihydro-1H-inden-1-one derivatives as potent FAK inhibitors for the treatment of ovarian cancer
Wei, Wei
Feng, Zhanzhan
Liu, Zhihao
Li, Xinyue
He, Hualong
Ran, Kai
Shi, Yaojie
Zhu, Yongxia
Ye, Tinghong
Gao, Chao
Wang, Ningyu
Yu, Luoting
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 228
[33] A Facile Synthesis and Docking Studies of N-(3-(4-Chlorophenoxy)benzyl)-2-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Bommera, Ravi Kumar
Merugu, Ramchander
Eppakayala, Laxminarayana
CHEMICAL METHODOLOGIES, 2019, 3 (03): : 360 - 367
[34] Design, synthesis and biological evaluation of substituted pyrrolo[2,3-d] pyrimidines as multiple receptor tyrosine kinase inhibitors and antiangiogenic agents
Gangjee, Aleem
Namjoshi, Ojas A.
Yu, Jianming
Ihnat, Michael A.
Thorpe, Jessica E.
Warnke, Linda A.
BIOORGANIC & MEDICINAL CHEMISTRY, 2008, 16 (10) : 5514 - 5528
[35] Synthesis and evaluation of thieno[2,3-d]pyrimidin-4(3H)-ones as potential antitubercular agents
Borate, Hanumant B.
Annadate, Ritesh A.
Vagh, Sandip S.
Pisal, Mahesh M.
Deokate, Sagar B.
Arkile, Manisha A.
Jadhav, Nandadeep J.
Nawale, Laxman U.
Sarkar, Dhiman
MEDCHEMCOMM, 2015, 6 (12) : 2209 - 2215
[36] Design, synthesis and biological evaluation of 7H-pyrrolo[2,3-d] pyrimidine derivatives containing 1,8-naphthyridine-4-one fragment
Zhang, Jianqing
Chen, Pengqin
Duan, Yongli
Xiong, Hehua
Li, Hongmin
Zeng, Yao
Liang, Guang
Tang, Qidong
Wu, Di
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 215
[37] Design, synthesis and evaluation of 2-amino-4-m-bromoanilino-6-arylmethyl-7H-pyrrolo[2,3-d]pyrimidines as tyrosine kinase inhibitors and antiangiogenic agents
Gangjee, Aleem
Zhao, Ying
Raghavan, Sudhir
Ihnat, Michael A.
Disch, Bryan C.
BIOORGANIC & MEDICINAL CHEMISTRY, 2010, 18 (14) : 5261 - 5273
[38] Design, synthesis and biological evaluation of novel 4-(pyrrolo[2,3-d]pyrimidine-4-yloxy)benzamide derivatives as potential antitumor agents
Zhang, Jianqing
Xiong, Hehua
Yang, Feiyi
He, Jie
Chen, Ting
Fu, Dongxue
Zheng, Pengwu
Tang, Qidong
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2021, 33
[39] 7-DEAZAPURINES .6. SYNTHESES AND REACTIONS OF 5,7-DIHYDRO-4-METHYL-2-PHENYL-7-SUBSTITUTED-6H-PYRROLO[2,3-D]PYRIMIDIN-6-ONES
SANTILLI, AA
SCOTESE, AC
KIM, DH
JOURNAL OF HETEROCYCLIC CHEMISTRY, 1976, 13 (01) : 135 - 137
[40] STUDIES IN NUCLEOSIDES .27. SYNTHESIS OF 2,4-BIS(METHYLTHIO)-5-METHYL-7-SUBSTITUTED-7H-PYRROLO[2,3-D]PYRIMIDINES AND THEIR BIOLOGICAL-ACTIVITY
DEO, K
AVASTHI, K
PRATAP, R
BHAKUNI, DS
JOSHI, MN
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 1990, 29 (05): : 459 - 463

← 1 2 3 4 5 →