Design, synthesis, and preclinical evaluation of 7-benzyl -N-substituted phenyl-5H-pyrrolo[3,2-d]pyrimidin-4-amines as single agents with antitubulin and antiangiogenic activity as antitumor agents

被引:0
|
作者
Gangjee, Aleem [1 ]
Pavana, Roheeth Kumar [1 ]
Ihnat, Michael A. [2 ]
Hamel, Ernest [3 ]
机构
[1] Duquesne Univ, Grad Sch Pharmaceut Sci, Div Med Chem, Pittsburgh, PA 15282 USA
[2] Univ Oklahoma, Hlth Sci Ctr, Coll Pharm, Dept Pharmaceut Sci, Oklahoma City, OK 73117 USA
[3] NCI, Screening Technol Branch, Dev Therapeut Program, Div Canc Treatment & Diag,Frederick Natl Lab Canc, Frederick, MD 21702 USA
关键词
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
321-MEDI
引用
收藏
页数:1
相关论文
共 36 条
  • [21] Design, synthesis and structure-activity relationships (SARs) studies of novel 4-substituted-2-amino-pyrido[3,4-d]pyrimidin-8(7H)-one analogs as potential antitumor agents
    Wei, Linyi
    Malhotra, Sanjay V.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2009, 238
  • [22] Design, synthesis and biological evaluation of 7-substituted 4-phenyl-6H-imidazo[1,5-a]thieno[3,2-f] [1,4]diazepines as safe anxiolytic agents
    Di Capua, Angela
    Reale, Annalisa
    Paolino, Marco
    Chemi, Giulia
    Brogi, Simone
    Cappelli, Andrea
    Giorgi, Gianluca
    Grande, Fedora
    Mannelli, Lorenzo Di Cesare
    Ghelardini, Carla
    Matucci, Rosanna
    Garofalo, Antonio
    Anzini, Maurizio
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 200
  • [23] Design, Synthesis, and Evaluation of the Antitubercular Activity of 5-Phenyl Substituted-5, 6-dihydropyrido[2, 3-d]pyrimidine-4, 7(3H, 8H)-dione Compounds
    Sun, Lianqi
    Kou, Shibo
    Wang, Bin
    Wang, Yongjian
    Meng, Jianzhou
    Liu, Tianfu
    Ma, Yuanyuan
    Zhao, Jianyuan
    Yi, Hong
    Cen, Shan
    Lu, Yu
    Li, Zhuorong
    JOURNAL OF MEDICINAL CHEMISTRY, 2024, 67 (17) : 14927 - 14945
  • [24] Design, synthesis, and evaluation of 4-(substituted)phenyl-2-thioxo-3,4-dihydro-1H-chromino[4,3-d]pyrimidin-5-one and 4-(substituted)phenyl-3,4-dihydro-1H-chromino[4,3-d]pyrimidine-2,5-dione analogs as antitubercular agents
    Ambre, Premlata K.
    Pissurlenkar, Raghuvir R. S.
    Wavhale, Ravindra D.
    Shaikh, Mushtaque S.
    Khedkar, Vijay M.
    Wan, Baojie
    Franzblau, Scott G.
    Coutinho, Evans C.
    MEDICINAL CHEMISTRY RESEARCH, 2014, 23 (05) : 2564 - 2575
  • [25] Design, synthesis, and evaluation of 4-(substituted)phenyl-2-thioxo-3,4-dihydro-1H-chromino[4,3-d]pyrimidin-5-one and 4-(substituted)phenyl-3,4-dihydro-1H-chromino[4,3-d]pyrimidine-2,5-dione analogs as antitubercular agents
    Premlata K. Ambre
    Raghuvir R. S. Pissurlenkar
    Ravindra D. Wavhale
    Mushtaque S. Shaikh
    Vijay M. Khedkar
    Baojie Wan
    Scott G. Franzblau
    Evans C. Coutinho
    Medicinal Chemistry Research, 2014, 23 : 2564 - 2575
  • [26] Synthesis and structure-activity relationship study of 2-(substituted benzylidene)-7-(4-fluorophenyl)-5-(furan-2-yl)-2H-thiazolo[3,2-a]pyrimidin-3(7H)-one derivatives as anticancer agents
    Selvam, Theivendran Panneer
    Karthick, Viswanathen
    Kumar, Palanirajan Vijayaraj
    Ali, Mohamed Ashraf
    DRUG DISCOVERIES AND THERAPEUTICS, 2012, 6 (04): : 198 - 204
  • [27] N2-Trimethylacetyl substituted and unsubstituted-N4-phenylsubstituted-6-(2-pyridin-2-ylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines: Design, cellular receptor tyrosine kinase inhibitory activities and in vivo evaluation as antiangiogenic, antimetastatic and antitumor agents
    Gangjee, Aleem
    Namjoshi, Ojas A.
    Yu, Jianming
    Ihnat, Michael A.
    Thorpe, Jessica E.
    Bailey-Downs, Lora C.
    BIOORGANIC & MEDICINAL CHEMISTRY, 2013, 21 (05) : 1312 - 1323
  • [28] Design, molecular modelling, synthesis, characterization studies of novel N-(7-(substituted benzylidene)-4-phenyl-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1-(substituted phenyl)methanimine against breast cancer
    Manoharan, Arunkumar
    Theivendren, Panneerselvam
    Sharma, Maya
    Kunjiappan, Selvaraj
    Govindaraj, Saravanan
    Pavadai, Parasuraman
    JOURNAL OF THE IRANIAN CHEMICAL SOCIETY, 2025, : 561 - 573
  • [29] Synthesis and preliminary evaluation of some N-[5-(2-furanyl)-2-methyl-4-oxo-4H-thieno[2,3-d]pyrimidin-3-yl]-carboxamide and 3-substituted-5-(2-furanyl)-2-methyl-3H-thieno[2,3-d]pyrimidin-4-ones as antimicrobial agents
    Chambhare, RV
    Khadse, BG
    Bobde, AS
    Bahekar, RH
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2003, 38 (01) : 89 - 100
  • [30] Synthesis and biological activity of N4-phenylsubstituted-6-(2,4-dichloro phenylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines as vascular endothelial growth factor receptor-2 inhibitors and antiangiogenic and antitumor agents
    Gangjee, Aleem
    Kurup, Sonali
    Ihnat, Michael A.
    Thorpe, Jessica E.
    Shenoy, Satyendra S.
    BIOORGANIC & MEDICINAL CHEMISTRY, 2010, 18 (10) : 3575 - 3587