Ruthenium-Catalyzed Oxidative Dearomatization of Indoles for the Construction of C2-Quaternary Indolin-3-ones

被引：29

作者：

Zhou, Xiao-Yu ^{[1
]}

Chen, Xia ^{[1
]}

Wang, Liang-Guang ^{[2
]}

Yang, Dan ^{[1
]}

Li, Jin-Hui ^{[1
]}

机构：

[1] Liupanshui Normal Univ, Sch Chem & Mat Engn, Liupanshui 553004, Peoples R China

[2] Anshun Univ, Coll Chem & Chem Engn, Anshun 561000, Peoples R China

来源：

SYNLETT | 2018年 / 29卷 / 06期

关键词：

ruthenium catalysis; oxidation; dearomatization; indoles; indolinones; N-BOC INDOLES; AEROBIC OXIDATION; ASYMMETRIC EPOXIDATION; MOLECULAR-OXYGEN; ALKALOIDS; ALCOHOLS; OLEFINS; EFFICIENT; ALKANES; ALDEHYDES;

D O I：

10.1055/s-0036-1591876

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A ruthenium-catalyzed oxidative dearomatization of 2-alkylor 2-aryl-substituted indoles has been developed. When coupled with a cascade transformation, it provides a new system for the construction of indolin-3-ones bearing a C2-quaternary functionality. The reaction occurs readily with RuCl3 center dot 3H(2)O as a catalyst in acetonitrile. 2-(3-Indolyl)substituted indolin-3-ones were obtained in medium to high yields. A mechanism for the reaction is also proposed.

引用

页码：835 / 839

页数：5

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