Ruthenium-Catalyzed Oxidative Dearomatization of Indoles for the Construction of C2-Quaternary Indolin-3-ones

被引：29
|
作者：
Zhou, Xiao-Yu [1 ]
Chen, Xia [1 ]
Wang, Liang-Guang [2 ]
Yang, Dan [1 ]
Li, Jin-Hui [1 ]
机构：
[1] Liupanshui Normal Univ, Sch Chem & Mat Engn, Liupanshui 553004, Peoples R China
[2] Anshun Univ, Coll Chem & Chem Engn, Anshun 561000, Peoples R China
来源：
SYNLETT | 2018年 / 29卷 / 06期
关键词：
ruthenium catalysis; oxidation; dearomatization; indoles; indolinones; N-BOC INDOLES; AEROBIC OXIDATION; ASYMMETRIC EPOXIDATION; MOLECULAR-OXYGEN; ALKALOIDS; ALCOHOLS; OLEFINS; EFFICIENT; ALKANES; ALDEHYDES;
D O I：
10.1055/s-0036-1591876
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A ruthenium-catalyzed oxidative dearomatization of 2-alkylor 2-aryl-substituted indoles has been developed. When coupled with a cascade transformation, it provides a new system for the construction of indolin-3-ones bearing a C2-quaternary functionality. The reaction occurs readily with RuCl3 center dot 3H(2)O as a catalyst in acetonitrile. 2-(3-Indolyl)substituted indolin-3-ones were obtained in medium to high yields. A mechanism for the reaction is also proposed.
引用
收藏
页码：835 / 839
页数：5
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