Ru-catalyzed oxidation and C-C bond formation of indoles for the synthesis of 2-indolyl indolin-3-ones under mild reaction conditions

被引：6
|
作者：
Zhou, Xiao-Yu [1 ]
Chen, Xia [1 ]
机构：
[1] Liupanshui Normal Univ, Sch Chem & Mat Engn, Liupanshui 553004, Peoples R China
来源：
CANADIAN JOURNAL OF CHEMISTRY | 2020年 / 98卷 / 11期
关键词：
ruthenium; oxidation; indoles; indolin-3-one; TBHP; N-BOC INDOLES; DEAROMATIZATION; MITOMYCIN; ISATINS;
D O I：
10.1139/cjc-2019-0288
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Herein, we described a ruthenium catalyzed oxidation and C-C bond formation reaction of 2-alkyl or 2-aryl substituted indoles using tert-butyl hydroperoxide (TBHP) as oxidant. Coupled with cascade transformation, it provided a mild catalytic oxidation system for the synthesis of 2-indolylindolin-3-ones. The reaction could readily occur using RuCl3 center dot 3H(2)O as catalyst, and the target product was obtained with medium to high yield.
引用
收藏
页码：667 / 669
页数：3
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