Ru-catalyzed oxidation and C-C bond formation of indoles for the synthesis of 2-indolyl indolin-3-ones under mild reaction conditions

被引：6

作者：

Zhou, Xiao-Yu ^{[1
]}

Chen, Xia ^{[1
]}

机构：

[1] Liupanshui Normal Univ, Sch Chem & Mat Engn, Liupanshui 553004, Peoples R China

来源：

CANADIAN JOURNAL OF CHEMISTRY | 2020年 / 98卷 / 11期

关键词：

ruthenium; oxidation; indoles; indolin-3-one; TBHP; N-BOC INDOLES; DEAROMATIZATION; MITOMYCIN; ISATINS;

D O I：

10.1139/cjc-2019-0288

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Herein, we described a ruthenium catalyzed oxidation and C-C bond formation reaction of 2-alkyl or 2-aryl substituted indoles using tert-butyl hydroperoxide (TBHP) as oxidant. Coupled with cascade transformation, it provided a mild catalytic oxidation system for the synthesis of 2-indolylindolin-3-ones. The reaction could readily occur using RuCl3 center dot 3H(2)O as catalyst, and the target product was obtained with medium to high yield.

引用

页码：667 / 669

页数：3

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