Pseudolaric Acid B Induces Caspase-Dependent Apoptosis and Autophagic Cell Death in Prostate Cancer Cells

被引：23
|
作者：
Tong, Jing [1 ]
Yin, Shutao [1 ]
Dong, Yinhui [1 ]
Guo, Xiao [1 ]
Fan, Lihong [2 ]
Ye, Min [3 ]
Hu, Hongbo [1 ]
机构：
[1] China Agr Univ, Coll Food Sci & Nutr Engn, Div Nutr & Hlth, Beijing 100083, Peoples R China
[2] China Agr Univ, Coll Vet Med, Beijing 100193, Peoples R China
[3] Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
来源：
PHYTOTHERAPY RESEARCH | 2013年 / 27卷 / 06期
基金：
中国国家自然科学基金;
关键词：
pseudolaric acid B; prostate cancer; apoptosis; autophagic cell death; sensitization; N-TERMINAL KINASE; SENSITIZATION; ARREST; AGENT; MCF-7; JNK; CHEMOPREVENTION; DITERPENOIDS; DEGRADATION; ACTIVATION;
D O I：
10.1002/ptr.4808
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Previous studies have shown that Pseudolaric acid B (PAB), a medicinal plant-derived terpenoid, is a promising chemopreventive or therapeutic agent against various types of cancer. However, less is known regarding its activity against prostate cancer. The objective of the current study is designed to determine the anti-prostate cancer effects of PAB. We demonstrated here that PAB was highly effective against both androgen-dependent (LNCaP) and androgen-independent prostate cancer cells (PC-3 and DU145) through the mechanisms involved in induction of G2/M cell cycle arrest, caspase-dependent apoptosis and autophagic cell death. Furthermore, PAB can greatly sensitize these two aggressive androgen-independent prostate cancer cells to ABT-737-induced cytotoxicity. Our findings suggest that PAB holds excellent potential as either novel chemopreventive agent or enhancer of therapeutic drug against prostate cancer. Copyright (c) 2012 John Wiley & Sons, Ltd.
引用
收藏
页码：885 / 891
页数：7
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