Pseudolaric Acid B Induces Caspase-Dependent Apoptosis and Autophagic Cell Death in Prostate Cancer Cells

被引：23
|
作者：
Tong, Jing [1 ]
Yin, Shutao [1 ]
Dong, Yinhui [1 ]
Guo, Xiao [1 ]
Fan, Lihong [2 ]
Ye, Min [3 ]
Hu, Hongbo [1 ]
机构：
[1] China Agr Univ, Coll Food Sci & Nutr Engn, Div Nutr & Hlth, Beijing 100083, Peoples R China
[2] China Agr Univ, Coll Vet Med, Beijing 100193, Peoples R China
[3] Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
来源：
PHYTOTHERAPY RESEARCH | 2013年 / 27卷 / 06期
基金：
中国国家自然科学基金;
关键词：
pseudolaric acid B; prostate cancer; apoptosis; autophagic cell death; sensitization; N-TERMINAL KINASE; SENSITIZATION; ARREST; AGENT; MCF-7; JNK; CHEMOPREVENTION; DITERPENOIDS; DEGRADATION; ACTIVATION;
D O I：
10.1002/ptr.4808
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Previous studies have shown that Pseudolaric acid B (PAB), a medicinal plant-derived terpenoid, is a promising chemopreventive or therapeutic agent against various types of cancer. However, less is known regarding its activity against prostate cancer. The objective of the current study is designed to determine the anti-prostate cancer effects of PAB. We demonstrated here that PAB was highly effective against both androgen-dependent (LNCaP) and androgen-independent prostate cancer cells (PC-3 and DU145) through the mechanisms involved in induction of G2/M cell cycle arrest, caspase-dependent apoptosis and autophagic cell death. Furthermore, PAB can greatly sensitize these two aggressive androgen-independent prostate cancer cells to ABT-737-induced cytotoxicity. Our findings suggest that PAB holds excellent potential as either novel chemopreventive agent or enhancer of therapeutic drug against prostate cancer. Copyright (c) 2012 John Wiley & Sons, Ltd.
引用
收藏
页码：885 / 891
页数：7
相关论文
共 50 条
  • [41] Ivermectin induces cell cycle arrest and caspase-dependent apoptosis in human urothelial carcinoma cells
    Tung, Chun-Liang
    Chao, Wen-Ying
    Li, Yi-Zhen
    Shen, Cheng-Huang
    Zhao, Pei-Wen
    Chen, Shu-Hsin
    Wu, Tzu-Yun
    Lee, Ying-Ray
    INTERNATIONAL JOURNAL OF MEDICAL SCIENCES, 2022, 19 (10): : 1567 - 1575
  • [42] Phenformin Induces Caspase-dependent Apoptosis of FaDu Head and Neck Squamous Cell Carcinoma Cells
    Seo, Yo-Seob
    Kim, Tae-Hyeon
    Lim, Hyangi
    Oh, Ji-Su
    You, Jae-Seek
    Lee, Gyeong-Je
    Yu, Sun-Kyoung
    Kim, Do Kyung
    Kim, Heung-Joong
    Kim, Chun Sung
    Lee, Sook-Young
    Kim, Su-Gwan
    Kim, Jae-Sung
    ANTICANCER RESEARCH, 2019, 39 (07) : 3499 - 3506
  • [43] FPDHP, a novel anticancer agent, induces cell detachment and caspase-dependent apoptosis in Caki cells
    Park, Jun Soo
    Kim, Wan Tae
    Kim, Shin
    Kwon, Taeg Kyu
    Jang, Byeong-Churl
    Lee, Eung-Seok
    Park, Jong Wook
    INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2014, 34 (04) : 1051 - 1056
  • [44] Tliptolide induces caspase-dependent cell death mediated via the mitochondfial pathway in leukemic cells
    Carter, Bing Z.
    Mak, Duncan H.
    Schober, Wendy D.
    McQueen, Teresa
    Harris, David
    Estrov, Zeev
    Evans, Randall L.
    Andreeff, Michael
    BLOOD, 2006, 108 (02) : 630 - 637
  • [45] Indospicine combined with arginine deprivation triggers cancer cell death via caspase-dependent apoptosis
    Shuvayeva, Galyna Y.
    Bobak, Yaroslav P.
    Vovk, Olena, I
    Kunz-Schughart, Leoni A.
    Fletcher, Mary T.
    Stasyk, Oleh, V
    CELL BIOLOGY INTERNATIONAL, 2021, 45 (03) : 518 - 527
  • [46] Motexafin gadolinium induces mitochondriallymediated caspase-dependent apoptosis
    J. Chen
    J. Ramos
    M. Sirisawad
    R. Miller
    L. Naumovski
    Apoptosis, 2005, 10 : 1131 - 1142
  • [47] Caspase-Dependent Apoptosis in Prostate Cancer Cells and Zebrafish by Corchorusoside C from Streptocaulon juventas
    Anaya-Eugenio, Gerardo D.
    Addo, Ermias Mekuria
    Ezzone, Nathan
    Henkin, Joshua M.
    Tran Ngoc Ninh
    Ren, Yulin
    Soejarto, Djaja D.
    Kinghorn, A. Douglas
    de Blanco, Esperanza J. Carcache
    JOURNAL OF NATURAL PRODUCTS, 2019, 82 (06): : 1645 - 1655
  • [48] Apop-1 Induces caspase-dependent Apoptosis
    Sun, Xin
    Lv, Gang
    Gao, Ling
    Kong, Fanli
    Zhu, Xiaotao
    Tian, Dan
    Tong, Haibin
    Chu, Xiaodan
    Xie, Yu
    2010 4TH INTERNATIONAL CONFERENCE ON BIOINFORMATICS AND BIOMEDICAL ENGINEERING (ICBBE 2010), 2010,
  • [49] The natural product honokiol induces caspase-dependent apoptosis in B-cell chronic lymphocytic leukemia (B-CLL) cells
    Battle, TE
    Arbiser, J
    Frank, DA
    BLOOD, 2005, 106 (02) : 690 - 697
  • [50] Baculovirus IAP1 induces caspase-dependent apoptosis in insect cells
    Ikeda, Motoko
    Yamada, Hayato
    Ito, Hiroyuki
    Kobayashi, Michihiro
    JOURNAL OF GENERAL VIROLOGY, 2011, 92 : 2654 - 2663
12345