γ-tocopherol induces apoptosis in androgen-responsive LNCaP prostate cancer cells via caspase-dependent and independent mechanisms

被引：34
|
作者：
Jiang, Q
Wong, J
Ames, BN
机构：
[1] Childrens Hosp, Oakland Res Inst, Oakland, CA 94609 USA
[2] Univ Calif Berkeley, Div Biochem & Mol Biol, Berkeley, CA 94720 USA
来源：
VITAMIN E AND HEALTH | 2004年 / 1031卷
关键词：
gamma-tocopherol; vitamin E; apoptosis; caspase; prostate cancer;
D O I：
10.1196/annals.1331.056
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We found that gamma-tocopherol, the predominant vitamin E form in diets, but not alpha-tocopherol, which is the exclusive form of vitamin E in most supplements, exhibited antiproliferation effect on prostate (PC-3, LNCaP) and lung (A549) cancer cells. gamma-Tocopherol induced apoptosis in androgen-sensitive LNCaP but not androgen-resistant PC-3 cells. Consequently, gamma-tocopherol treatment caused cytochrome c release and caspase-9, -3 and -7 activation. However, the apoptosis could not be completely reversed by an irreversible pancaspase inhibitor, indicating that an alternative caspase-independent pathway may also be involved. Our study suggests that gamma-tocopherol may be valuable in the prevention and therapy for certain types of cancer.
引用
收藏
页码：399 / 400
页数：2
相关论文
共 50 条
  • [1] Decoy of androgen-responsive element induces apoptosis in LNCaP cells
    Kuratsukuri, K
    Sugimura, K
    Harimoto, K
    Kawashima, H
    Kishimoto, T
    PROSTATE, 1999, 41 (02): : 121 - 126
  • [2] Decoy of androgen-responsive element induces apoptosis in LNCaP cells
    不详
    EUROPEAN UROLOGY SUPPLEMENTS, 2005, 4 (03) : 156 - 156
  • [3] Lycopene differentially induces quiescence and apoptosis in androgen-responsive and -independent prostate cancer cell lines
    Ivanov, Nikita I.
    Cowell, Simon P.
    Brown, Paula
    Rennie, Paul S.
    Guns, Emma S.
    Cox, Michael E.
    CLINICAL NUTRITION, 2007, 26 (02) : 252 - 263
  • [4] Enterolactone induces apoptosis in human prostate carcinoma LNCaP cells via a mitochondrial-mediated, caspase-dependent pathway
    Chen, Li-Hua
    Fang, Jing
    Li, Huaixing
    Demark-Wahnefried, Wendy
    Lin, Xu
    MOLECULAR CANCER THERAPEUTICS, 2007, 6 (09) : 2581 - 2590
  • [5] Raloxifene, a selective estrogen receptor modulator, induces apoptosis in androgen-responsive human prostate cancer cell line LNCaP through an androgen-independent pathway
    Kim, IY
    Seong, DW
    Kim, BC
    Lee, DK
    Remaley, AT
    Leach, F
    Morton, RA
    Kim, SJ
    CANCER RESEARCH, 2002, 62 (13) : 3649 - 3653
  • [6] Raloxifene, a selective estrogen receptor modulator, induces apoptosis in androgen-responsive human prostate cancer cell line, LNCaP, through an androgen-independent pathway
    Kim, IY
    Lee, DH
    Remaley, AT
    Leach, F
    Kim, SJ
    Morton, RA
    JOURNAL OF UROLOGY, 2002, 167 (04): : 49 - 49
  • [7] Docetaxel induces prostate cancer cell death via caspase-dependent and independent pathways
    Mediavilla-Varela, Melanie
    Ganapathy, Vidya
    Daniels, Tracy R.
    Casiano, Carlos A.
    CANCER RESEARCH, 2006, 66 (08)
  • [8] Staurosporine induces apoptosis through both caspase-dependent and caspase-independent mechanisms
    Belmokhtar, CA
    Hillion, J
    Ségal-Bendirdjian, E
    ONCOGENE, 2001, 20 (26) : 3354 - 3362
  • [9] Staurosporine induces apoptosis through both caspase-dependent and caspase-independent mechanisms
    Chafké Ahmed Belmokhtar
    Josette Hillion
    Evelyne Ségal-Bendirdjian
    Oncogene, 2001, 20 : 3354 - 3362
  • [10] Cadmium Induces Thymocyte Apoptosis via Caspase-Dependent and Caspase-Independent Pathways
    Pathak, Neelima
    Mitra, Sumonto
    Khandelwal, Shashi
    JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 2013, 27 (03) : 193 - 203
12345