Excitatory connections between the prelimbic and infralimbic medial prefrontal cortex show a role for the prelimbic cortex in fear extinction

被引：73

作者：

Marek, Roger ^{[1
]}

Xu, Li ^{[1
]}

Sullivan, Robert K. P. ^{[1
]}

Sah, Pankaj ^{[1
]}

机构：

[1] Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia

来源：

NATURE NEUROSCIENCE | 2018年 / 21卷 / 05期

基金：

英国医学研究理事会; 澳大利亚研究理事会;

关键词：

CONDITIONED FEAR; NEURONS; PROJECTIONS; EXPRESSION; AMYGDALA; RAT; MEMORY;

D O I：

10.1038/s41593-018-0137-x

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We elucidated the intrinsic circuitry of the medial prefrontal cortex and its role in regulating fear extinction, using neuronal tracing and optogenetic stimulation in vitro and in vivo. We show that pyramidal neurons in layer 5/6 of the prelimbic medial prefrontal cortex project to pyramidal cells in layer 5/6 of the infralimbic cortex. Activation of this connection enhances fear extinction, redefining the role of the prelimbic cortex in extinction learning.

引用

页码：654 / +

页数：7

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