Excitatory connections between the prelimbic and infralimbic medial prefrontal cortex show a role for the prelimbic cortex in fear extinction

被引：73

作者：

Marek, Roger ^{[1
]}

Xu, Li ^{[1
]}

Sullivan, Robert K. P. ^{[1
]}

Sah, Pankaj ^{[1
]}

机构：

[1] Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia

来源：

NATURE NEUROSCIENCE | 2018年 / 21卷 / 05期

基金：

英国医学研究理事会; 澳大利亚研究理事会;

关键词：

CONDITIONED FEAR; NEURONS; PROJECTIONS; EXPRESSION; AMYGDALA; RAT; MEMORY;

D O I：

10.1038/s41593-018-0137-x

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We elucidated the intrinsic circuitry of the medial prefrontal cortex and its role in regulating fear extinction, using neuronal tracing and optogenetic stimulation in vitro and in vivo. We show that pyramidal neurons in layer 5/6 of the prelimbic medial prefrontal cortex project to pyramidal cells in layer 5/6 of the infralimbic cortex. Activation of this connection enhances fear extinction, redefining the role of the prelimbic cortex in extinction learning.

引用

页码：654 / +

页数：7

共 50 条

[1] Excitatory connections between the prelimbic and infralimbic medial prefrontal cortex show a role for the prelimbic cortex in fear extinction
Roger Marek
Li Xu
Robert K. P. Sullivan
Pankaj Sah
[J]. Nature Neuroscience, 2018, 21 : 654 - 658
[2] Inactivation of the infralimbic but not the prelimbic cortex impairs consolidation and retrieval of fear extinction
Laurent, Vincent
Westbrook, R. Frederick
[J]. LEARNING & MEMORY, 2009, 16 (09) : 520 - 529
[3] Inactivating the infralimbic but not prelimbic medial prefrontal cortex facilitates the extinction of appetitive Pavlovian conditioning in Long-Evans rats
Mendoza, J.
Sanio, C.
Chaudhri, N.
[J]. NEUROBIOLOGY OF LEARNING AND MEMORY, 2015, 118 : 198 - 208
[4] Infralimbic and prelimbic prefrontal cortex activation is necessary to the enhancement of aversive memory extinction promoted by reactivation
Vargas, Liane da Silva
Lima, Karine Ramires
Mello-Carpes, Pamela B.
[J]. BRAIN RESEARCH, 2021, 1770
[5] Efferent projections of infralimbic and prelimbic areas of the medial prefrontal cortex in the Japanese monkey, Macaca fuscata
Chiba, T
Kayahara, T
Nakanoh, K
[J]. BRAIN RESEARCH, 2001, 888 (01) : 83 - 101
[6] Prelimbic and Infralimbic Prefrontal Cortex Interact during Fast Network Oscillations
van Aerde, Karlijn I.
Heistek, Tim S.
Mansvelder, Huibert D.
[J]. PLOS ONE, 2008, 3 (07):
[7] Loss of Hierarchical Control by Occasion Setters Following Lesions of the Prelimbic and Infralimbic Medial Prefrontal Cortex in Rats
Roughley, Stephanie
Killcross, Simon
[J]. BRAIN SCIENCES, 2019, 9 (03)
[8] Hippocampal Inputs in the Prelimbic Cortex Curb Fear after Extinction
Szadzinska, Weronika
Danielewski, Konrad
Kondrakiewicz, Kacper
Andraka, Karolina
Nikolaev, Evgeni
Mikosz, Marta
Knapska, Ewelina
[J]. JOURNAL OF NEUROSCIENCE, 2021, 41 (44): : 9129 - 9140
[9] ROLE OF PRELIMBIC MEDIAL PREFRONTAL CORTEX NEURONS IN REWARD PREDICTION ERROR SIGNALING
Hou, S.
Glover, E. J.
[J]. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 2022, 46 : 81A - 81A
[10] Differential projections of the infralimbic and prelimbic cortex in the rat
Vertes, RP
[J]. SYNAPSE, 2004, 51 (01) : 32 - 58

← 1 2 3 4 5 →