Cytotoxic ent-Kaurane Diterpenoids from Isodon nervosus

被引：8
|
作者：
Gao, You-Heng [1 ]
Wei, Zhi-Xiong [2 ]
Cheng, Yi [1 ]
Wang, Teng-Hua [1 ]
Ni, Lin [1 ]
Zhou, Xiao-Hong [1 ]
Zhang, Li-Yuan [1 ]
机构：
[1] Guangzhou Univ Chinese Med, Dept Phytochem, Sch Chinese Mat Med, Guangzhou 510006, Guangdong, Peoples R China
[2] DongGuan Inst Food & Drug Control, Dongguan 523106, Peoples R China
来源：
CHEMISTRY & BIODIVERSITY | 2013年 / 10卷 / 08期
关键词：
Isodon nervosus; ent-Kaurane diterpenoids; Terpenoids; Rabdonervosins G-J; Cytotoxic activity;
D O I：
10.1002/cbdv.201200201
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Four new ent-kaurane diterpenoids, rabdonervosins G-J (1-4, resp.), were isolated from the leaves and stems of Isodon nervosus. Their structures were elucidated by extensive spectroscopic analyses, including 1D-, 2D-NMR and HR mass spectra. Compound 2 showed potent cytotoxicity against the HepG2 and PC-9/ZD cell lines with IC50 values of 2.36 and 6.07M, respectively, and compound 3 exhibited cytotoxicity against the HepG2 and CNE2 cell lines with IC50 values of 8.64 and 9.77M, respectively.
引用
收藏
页码：1487 / 1493
页数：7
相关论文
共 50 条
  • [1] ent-kaurane diterpenoids from Isodon nervosus
    Li, Li-Mei
    Li, Guo-You
    Ding, Li-Sheng
    Yang, Li-Bin
    Zhao, Yong
    Pu, Han-Xin
    Xiao, Wei-Lie
    Han, Quan-Bin
    Sun, Han-Dong
    JOURNAL OF NATURAL PRODUCTS, 2008, 71 (04): : 684 - 688
  • [2] Cytotoxic ent-kaurane diterpenoids from Isodon eriocalyx
    Shen, YH
    Wen, ZY
    Xu, G
    Xiao, WL
    Peng, LY
    Lin, ZW
    Sun, HD
    CHEMISTRY & BIODIVERSITY, 2005, 2 (12) : 1665 - 1672
  • [3] Cytotoxic ent-Kaurane Diterpenoids from Isodon henryi
    Hu, Zhuo
    Zhan, Rui
    Du, Xue
    Su, Jia
    Li, Xiao-Nian
    Yang, Jian-Hong
    Zhang, Hai-Bo
    Li, Yan
    Sun, Han-Dong
    Li, Gan-Peng
    Pu, Jian-Xin
    CHEMICAL & PHARMACEUTICAL BULLETIN, 2011, 59 (12) : 1562 - 1566
  • [4] Cytotoxic ent-Kaurane Diterpenoids from Isodon wikstroemioides
    Wu, Hai-Yan
    Zhan, Rui
    Wang, Wei-Guang
    Jiang, Hua-Yi
    Du, Xue
    Li, Xiao-Nian
    Li, Yan
    Pu, Jian-Xin
    Sun, Han-Dong
    JOURNAL OF NATURAL PRODUCTS, 2014, 77 (04): : 931 - 941
  • [5] Cytotoxic ent-kaurane diterpenoids from Isodon macrophyllus
    Zhang, Ji-Xia
    He, Zhi-An
    Chen, Zheng-Yue
    Wang, Yong-Xue
    Bai, Su-Ping
    Sun, Han-Dong
    JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2009, 11 (08) : 693 - 697
  • [6] Cytotoxic ent-Kaurane Diterpenoids from Isodon henryi
    Zhao, Yong
    Huang, Sheng-Xiong
    Yang, Li-Bin
    Pu, Jian-Xin
    Xiao, Wei-Lie
    Li, Li-Mei
    Lei, Chun
    Weng, Zhi-Ying
    Han, Quan-Bin
    Sun, Han-Dong
    PLANTA MEDICA, 2009, 75 (01) : 65 - 69
  • [7] Cytotoxic ent-kaurane diterpenoids from Isodon sinuolata
    He, Fei
    Xiao, Wei-Lie
    Pu, Jian-Xin
    Wu, Ying-Li
    Zhang, Hai-Bo
    Li, Xiao-Nian
    Zhao, Yong
    Yang, Li-Bin
    Chen, Guo-Qiang
    Sun, Han-Dong
    PHYTOCHEMISTRY, 2009, 70 (11-12) : 1462 - 1466
  • [8] Cytotoxic ent-kaurane diterpenoids from Isodon sculponeata
    Jiang, B
    Hou, AJ
    Li, ML
    Li, SH
    Han, QB
    Wang, SJ
    Lin, ZW
    Sun, HD
    PLANTA MEDICA, 2002, 68 (10) : 921 - 925
  • [9] A new ent-kaurane diterpenoid from Isodon nervosus
    Yana, FuLin
    Wang, ChunMing
    Gua, LanQing
    Zhang, JiXia
    Bai, SuPing
    JOURNAL OF CHEMICAL RESEARCH-S, 2008, (09): : 522 - 524
  • [10] ent-Kaurane diterpenoids from Isodon japonicus
    Yang, Li-Bin
    Huang, Sheng-Xiong
    Li, Li-Mei
    Zhao, Yong
    Lei, Chun
    Xiao, Wei-Lie
    Pu, Jian-Xin
    Han, Quan-Bin
    Sun, Han-Dong
    HELVETICA CHIMICA ACTA, 2007, 90 (12) : 2375 - 2379
12345