Cytotoxic ent-Kaurane Diterpenoids from Isodon wikstroemioides

被引：19
|
作者：
Wu, Hai-Yan [1 ,2 ]
Zhan, Rui [1 ]
Wang, Wei-Guang [1 ]
Jiang, Hua-Yi [1 ,2 ]
Du, Xue [1 ]
Li, Xiao-Nian [1 ]
Li, Yan [1 ]
Pu, Jian-Xin [1 ]
Sun, Han-Dong [1 ]
机构：
[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
来源：
JOURNAL OF NATURAL PRODUCTS | 2014年 / 77卷 / 04期
基金：
中国科学院西部之光基金; 中国国家自然科学基金;
关键词：
RUBESCENS VAR.-TAIHANGENSIS; KAURENE DITERPENOIDS; MAOECRYSTAL-V; C-H; ERIOCALYX; SKELETON;
D O I：
10.1021/np4010135
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Phytochemical investigation of EtOAc extracts of the aerial parts of Isodon wikstroemioides afforded 18 new ent-kaurane diterpenoids (wikstroemioidins E-V, 1-18), along with 17 known analogues (19-35). The absolute configurations of 1 and 16 were confirmed by single-crystal X-ray diffraction analysis. The isolates were screened against five human tumor cell lines; compounds 3, 4, 9, 11-13, 23, 25-28, and 33 exhibited significant cytotoxic activity against all five, with IC50 values ranging from 0.4 to 5.1 mu M. In addition, 17 of the isolates strongly inhibited nitric oxide production in LPS-activated RAW264.7 macrophages.
引用
收藏
页码：931 / 941
页数：11
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