Cytotoxic ent-Kaurane Diterpenoids from Isodon wikstroemioides

被引：19
|
作者：
Wu, Hai-Yan [1 ,2 ]
Zhan, Rui [1 ]
Wang, Wei-Guang [1 ]
Jiang, Hua-Yi [1 ,2 ]
Du, Xue [1 ]
Li, Xiao-Nian [1 ]
Li, Yan [1 ]
Pu, Jian-Xin [1 ]
Sun, Han-Dong [1 ]
机构：
[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
来源：
JOURNAL OF NATURAL PRODUCTS | 2014年 / 77卷 / 04期
基金：
中国科学院西部之光基金; 中国国家自然科学基金;
关键词：
RUBESCENS VAR.-TAIHANGENSIS; KAURENE DITERPENOIDS; MAOECRYSTAL-V; C-H; ERIOCALYX; SKELETON;
D O I：
10.1021/np4010135
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Phytochemical investigation of EtOAc extracts of the aerial parts of Isodon wikstroemioides afforded 18 new ent-kaurane diterpenoids (wikstroemioidins E-V, 1-18), along with 17 known analogues (19-35). The absolute configurations of 1 and 16 were confirmed by single-crystal X-ray diffraction analysis. The isolates were screened against five human tumor cell lines; compounds 3, 4, 9, 11-13, 23, 25-28, and 33 exhibited significant cytotoxic activity against all five, with IC50 values ranging from 0.4 to 5.1 mu M. In addition, 17 of the isolates strongly inhibited nitric oxide production in LPS-activated RAW264.7 macrophages.
引用
收藏
页码：931 / 941
页数：11
相关论文
共 50 条
  • [41] Two new ent-kaurane diterpenoids from Isodon adenantha
    Jiang, B
    Xu, JC
    Yang, H
    Zhao, QS
    Sun, HD
    CHINESE CHEMICAL LETTERS, 2000, 11 (11) : 995 - 996
  • [42] Two new ent-kaurane diterpenoids from Isodon excisoides
    Zhang, Ji Xia
    Wang, Yong Xue
    He, Zhi An
    Yan, Fu Lin
    Sun, Han Dong
    CHINESE CHEMICAL LETTERS, 2009, 20 (02) : 201 - 203
  • [43] Two new ent-kaurane diterpenoids from Isodon macrophyllus
    Zhang, Ji Xia
    Chen, Zheng Yue
    Wang, Yong Xue
    Qiu, Pei Yong
    Huang, Sheng Xiong
    Sun, Han Dong
    JOURNAL OF CHEMICAL RESEARCH, 2006, (07) : 420 - 421
  • [44] Two New ent-Kaurane Diterpenoids from Isodon japonica
    Ji Xia ZHANG2
    Chinese Chemical Letters, 2002, (11) : 1075 - 1078
  • [45] Bioactive Abietane and ent-Kaurane Diterpenoids from Isodon tenuifolius
    Yang, Jian-Hong
    Du, Xue
    He, Fei
    Zhang, Hai-Bo
    Li, Xiao-Nian
    Su, Jia
    Li, Yan
    Pu, Jian-Xin
    Sun, Han-Dong
    JOURNAL OF NATURAL PRODUCTS, 2013, 76 (02): : 256 - 264
  • [46] Two new ent-kaurane diterpenoids from Isodon henryi
    Yong Zhao~(a
    Chinese Chemical Letters, 2008, (09) : 1096 - 1098
  • [47] New ent-Abietane and ent-Kaurane Diterpenoids from Isodon rubescens
    Liu, Xu
    Zhan, Rui
    Wang, Wei-Guang
    Du, Xue
    Li, Xiao-Nian
    Yang, Jian-Hong
    Zhang, Peng
    Li, Yan
    Pu, Jian-Xin
    Wu, Ji-Zhou
    Sun, Han-Dong
    CHEMICAL & PHARMACEUTICAL BULLETIN, 2013, 61 (01) : 90 - 95
  • [48] Cytotoxic ent-kaurane diterpenoids from Isodon weisiensis C. Y.!Wu
    Ding, L
    Liu, GA
    Yang, DJ
    Wang, H
    Wang, L
    Sun, K
    PHARMAZIE, 2005, 60 (06): : 458 - 460
  • [49] Cytotoxic ent-Kaurane Diterpenoids from Rabdosia Rubescens
    Wei, Wen-Jun
    Zhu, Bingqiang
    Si, Yanpo
    Guo, Tao
    Kang, Jihong
    Dai, Liping
    CHEMISTRY & BIODIVERSITY, 2022, 19 (10)
  • [50] Ent-kaurane diterpenoids from Isodon rubescens var. rubescens
    Han, QB
    Xiao, WL
    Shen, YH
    Sun, HD
    CHEMICAL & PHARMACEUTICAL BULLETIN, 2004, 52 (06) : 767 - 769
12345