Cytotoxic ent-Kaurane Diterpenoids from Isodon nervosus

被引：8
|
作者：
Gao, You-Heng [1 ]
Wei, Zhi-Xiong [2 ]
Cheng, Yi [1 ]
Wang, Teng-Hua [1 ]
Ni, Lin [1 ]
Zhou, Xiao-Hong [1 ]
Zhang, Li-Yuan [1 ]
机构：
[1] Guangzhou Univ Chinese Med, Dept Phytochem, Sch Chinese Mat Med, Guangzhou 510006, Guangdong, Peoples R China
[2] DongGuan Inst Food & Drug Control, Dongguan 523106, Peoples R China
来源：
CHEMISTRY & BIODIVERSITY | 2013年 / 10卷 / 08期
关键词：
Isodon nervosus; ent-Kaurane diterpenoids; Terpenoids; Rabdonervosins G-J; Cytotoxic activity;
D O I：
10.1002/cbdv.201200201
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Four new ent-kaurane diterpenoids, rabdonervosins G-J (1-4, resp.), were isolated from the leaves and stems of Isodon nervosus. Their structures were elucidated by extensive spectroscopic analyses, including 1D-, 2D-NMR and HR mass spectra. Compound 2 showed potent cytotoxicity against the HepG2 and PC-9/ZD cell lines with IC50 values of 2.36 and 6.07M, respectively, and compound 3 exhibited cytotoxicity against the HepG2 and CNE2 cell lines with IC50 values of 8.64 and 9.77M, respectively.
引用
收藏
页码：1487 / 1493
页数：7
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