Cytotoxic ent-Kaurane Diterpenoids from Isodon nervosus

被引：8

作者：

Gao, You-Heng ^{[1
]}

Wei, Zhi-Xiong ^{[2
]}

Cheng, Yi ^{[1
]}

Wang, Teng-Hua ^{[1
]}

Ni, Lin ^{[1
]}

Zhou, Xiao-Hong ^{[1
]}

Zhang, Li-Yuan ^{[1
]}

机构：

[1] Guangzhou Univ Chinese Med, Dept Phytochem, Sch Chinese Mat Med, Guangzhou 510006, Guangdong, Peoples R China

[2] DongGuan Inst Food & Drug Control, Dongguan 523106, Peoples R China

来源：

CHEMISTRY & BIODIVERSITY | 2013年 / 10卷 / 08期

关键词：

Isodon nervosus; ent-Kaurane diterpenoids; Terpenoids; Rabdonervosins G-J; Cytotoxic activity;

D O I：

10.1002/cbdv.201200201

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Four new ent-kaurane diterpenoids, rabdonervosins G-J (1-4, resp.), were isolated from the leaves and stems of Isodon nervosus. Their structures were elucidated by extensive spectroscopic analyses, including 1D-, 2D-NMR and HR mass spectra. Compound 2 showed potent cytotoxicity against the HepG2 and PC-9/ZD cell lines with IC50 values of 2.36 and 6.07M, respectively, and compound 3 exhibited cytotoxicity against the HepG2 and CNE2 cell lines with IC50 values of 8.64 and 9.77M, respectively.

引用

页码：1487 / 1493

页数：7

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