Coexistence of light chain disease and chronic lymphocytic leukaemia, a complex karyotype with a rapid fatal outcome

被引：0
|
作者：
Castryck, H
Van den Driessche, M
Hagemeijer, A
Stul, M
Wynendaele, W
Vandenberghe, P
Moerman, J
机构：
[1] Imelda Hosp, Lab Clin Biol, B-2820 Bonheiden, Belgium
[2] Catholic Univ Louvain, Ctr Human Genet, B-3000 Louvain, Belgium
[3] Imelda Hosp, Dept Oncol, B-2820 Bonheiden, Belgium
来源：
CLINICAL AND LABORATORY HAEMATOLOGY | 2006年 / 28卷 / 02期
关键词：
CLL; FISH; molecular diagnosis; myeloma;
D O I：
10.1111/j.1365-2257.2006.00762.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
We report on a 48-year-old man with concomitantly diagnosed kappa expressing chronic lymphocytic leukaemia (CLL) and lambda light chain disease with highly complex chromosomal aberrations. The clinical course of the disease was very aggressive with survival of only 1 month. We demonstrate the distinct clonal origin by cytogenetic data and immunoglobulin rearrangement studies. To our knowledge this is the first report of a light chain disease associated with CLL.
引用
收藏
页码：138 / 140
页数：3
相关论文
共 50 条
  • [1] The landscape of genetic mutations in patients with chronic lymphocytic leukaemia and complex karyotype
    Strati, Paolo
    Wang, Feng
    Tambaro, Francesco P.
    Thompson, Philip A.
    Burger, Jan A.
    Jain, Nitin
    Ferrajoli, Alessandra
    Bose, Prithviraj
    Estrov, Zeev
    Keating, Michael J.
    Futreal, Andrew
    Takahashi, Koichi
    Wierda, William G.
    BRITISH JOURNAL OF HAEMATOLOGY, 2019, 187 (01) : E1 - E4
  • [2] Management strategies for patients with chronic lymphocytic leukaemia harbouring complex karyotype
    Serafin, Andrea
    Ruocco, Valeria
    Cellini, Alessandro
    Angotzi, Francesco
    Bonaldi, Laura
    Trentin, Livio
    Visentin, Andrea
    BRITISH JOURNAL OF HAEMATOLOGY, 2025, 206 (03) : 832 - 841
  • [3] Rare and fatal complications of an indolent disease - chronic lymphocytic leukaemia
    Jaggia, A.
    Hamblin, M.
    JOURNAL OF THE ROYAL COLLEGE OF PHYSICIANS OF EDINBURGH, 2008, 38 (02): : 120 - 122
  • [4] In chronic lymphocytic leukaemia with complex karyotype, major structural abnormalities identify a subset of patients with inferior outcome and distinct biological characteristics
    Rigolin, Gian Matteo
    Saccenti, Elena
    Guardalben, Emanuele
    Cavallari, Maurizio
    Formigaro, Luca
    Zagatti, Barbara
    Visentin, Andrea
    Mauro, Francesca R.
    Lista, Enrico
    Bassi, Cristian
    Lupini, Laura
    Quaglia, Francesca Maria
    Urso, Antonio
    Bardi, Maria Antonella
    Bonaldi, Laura
    Volta, Eleonora
    Tammiso, Elisa
    Ilari, Caterina
    Cafforio, Luciana
    Melandri, Aurora
    Cavazzini, Francesco
    Negrini, Massimo
    Semenzato, Gianpietro
    Trentin, Livio
    Foa, Robin
    Cuneo, Antonio
    BRITISH JOURNAL OF HAEMATOLOGY, 2018, 181 (02) : 229 - 233
  • [5] IN CHRONIC LYMPHOCYTIC LEUKAEMIA WITH COMPLEX KARYOTYPE, MAJOR STRUCTURAL ABNORMALITIES IDENTIFY A SUBSET OF PATIENTS WITH INFERIOR OUTCOME AND DISTINCT BIOLOGIC CHARACTERISTICS
    Cavallari, M.
    Rigolin, G. M.
    Saccenti, E.
    Guardalben, E.
    Formigaro, L.
    Zagatti, B.
    Visentin, A.
    Mauro, F. R.
    Lista, E.
    Bassi, C.
    Lupini, L.
    Quaglia, F. M.
    Urso, A.
    Bardi, M. A.
    Bonaldi, L.
    Volta, E.
    Tammiso, E.
    Ilari, C.
    Cafforio, L.
    Melandri, A.
    Cavazzini, F.
    Negrini, M.
    Semenzato, G.
    Trentin, L.
    Foa, R.
    Cuneo, A.
    HAEMATOLOGICA, 2018, 103 : S28 - S29
  • [6] Complex karyotype in patients with chronic lymphocytic leukemia.
    Yañez, L
    Cuadrado, MA
    Insunza, A
    Mesones, BG
    Bermudez, A
    Conde, E
    Bureo, E
    Iriondo, A
    BLOOD, 2005, 106 (11) : 328B - 328B
  • [7] Exploring the prognostic role of complex karyotype in chronic lymphocytic leukaemia patients treated with venetoclax-based regimens
    Serafin, Andrea
    Cellini, Alessandro
    Cavarretta, Chiara Adele
    Ruocco, Valeria
    Angotzi, Francesco
    Zatta, Ivan
    Frezzato, Federica
    Bonaldi, Laura
    Martines, Annalisa
    Pravato, Stefano
    Piazza, Francesco
    Trentin, Livio
    Visentin, Andrea
    BRITISH JOURNAL OF HAEMATOLOGY, 2024, 205 (01) : 189 - 193
  • [8] Fatal legionella pneumonia after fludarabine treatment in chronic lymphocytic leukaemia
    Hendrick, A
    JOURNAL OF CLINICAL PATHOLOGY, 2001, 54 (05) : 412 - 413
  • [9] Chronic lymphocytic leukaemia: one disease or two?
    Hamblin, T
    ANNALS OF HEMATOLOGY, 2002, 81 (06) : 299 - 303
  • [10] The prevalence of ocular disease in chronic lymphocytic leukaemia
    Buchan, J
    McKibbin, M
    Burton, T
    EYE, 2003, 17 (01) : 27 - 30
12345