Coexistence of light chain disease and chronic lymphocytic leukaemia, a complex karyotype with a rapid fatal outcome

被引：0

作者：

Castryck, H

Van den Driessche, M

Hagemeijer, A

Stul, M

Wynendaele, W

Vandenberghe, P

Moerman, J

机构：

[1] Imelda Hosp, Lab Clin Biol, B-2820 Bonheiden, Belgium

[2] Catholic Univ Louvain, Ctr Human Genet, B-3000 Louvain, Belgium

[3] Imelda Hosp, Dept Oncol, B-2820 Bonheiden, Belgium

来源：

CLINICAL AND LABORATORY HAEMATOLOGY | 2006年 / 28卷 / 02期

关键词：

CLL; FISH; molecular diagnosis; myeloma;

D O I：

10.1111/j.1365-2257.2006.00762.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report on a 48-year-old man with concomitantly diagnosed kappa expressing chronic lymphocytic leukaemia (CLL) and lambda light chain disease with highly complex chromosomal aberrations. The clinical course of the disease was very aggressive with survival of only 1 month. We demonstrate the distinct clonal origin by cytogenetic data and immunoglobulin rearrangement studies. To our knowledge this is the first report of a light chain disease associated with CLL.

引用

页码：138 / 140

页数：3

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