Coexistence of light chain disease and chronic lymphocytic leukaemia, a complex karyotype with a rapid fatal outcome

被引：0

作者：

Castryck, H

Van den Driessche, M

Hagemeijer, A

Stul, M

Wynendaele, W

Vandenberghe, P

Moerman, J

机构：

[1] Imelda Hosp, Lab Clin Biol, B-2820 Bonheiden, Belgium

[2] Catholic Univ Louvain, Ctr Human Genet, B-3000 Louvain, Belgium

[3] Imelda Hosp, Dept Oncol, B-2820 Bonheiden, Belgium

来源：

CLINICAL AND LABORATORY HAEMATOLOGY | 2006年 / 28卷 / 02期

关键词：

CLL; FISH; molecular diagnosis; myeloma;

D O I：

10.1111/j.1365-2257.2006.00762.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report on a 48-year-old man with concomitantly diagnosed kappa expressing chronic lymphocytic leukaemia (CLL) and lambda light chain disease with highly complex chromosomal aberrations. The clinical course of the disease was very aggressive with survival of only 1 month. We demonstrate the distinct clonal origin by cytogenetic data and immunoglobulin rearrangement studies. To our knowledge this is the first report of a light chain disease associated with CLL.

引用

页码：138 / 140

页数：3

共 50 条

[21] PULMONARY LIGHT CHAIN DEPOSIT DISEASE IN A PATIENT WITH CHRONIC LYMPHOCYTIC LEUKEMIA
Romera Martinez, I
Gonzalez Santillana, C., I
Lerma Verdejo, A.
de Camino Gaisse, Perez B.
Alarcon Tomas, A.
Naya Errea, D.
Alamo Moreno, J. R.
Alonso Trillo, R.
Fores Cachon, R.
De Laiglesia Lorenzo, A.
Laporta, R.
Cabrera Marin, R.
Garcia-Marco, J. A.
HAEMATOLOGICA, 2018, 103 : 221 - 221
[22] Clinicopathological features and outcome of chronic lymphocytic leukaemia in Chinese patients
Chan, Thomas Sau-Yan
Lee, Yuh-Shan
Del Giudice, Ilaria
Marinelli, Marilisa
Ilari, Caterina
Cafforio, Luciana
Guarini, Anna
Tan, Daryl
Phipps, Colin
Goh, Yeow-Tee
Hwang, William
Goh, Allan Zhi-Kai
Siu, Lisa Lai-Ping
Wu, Saliangi
Ha, Chun-Yin
Lin, Shek-Ying
Kwok, Chi-Hang
Lau, Chi-Kuen
Wong, Kit-Fai
Foa, Robin
Kwong, Yok-Lam
Tse, Eric
ONCOTARGET, 2017, 8 (15) : 25455 - 25468
[23] Chronic lymphocytic leukemia is becoming more complex: how to define complex karyotype?
Kreinitz, Natalia
Polliack, Aaron
Tadmor, Tamar
LEUKEMIA & LYMPHOMA, 2018, 59 (03) : 521 - 522
[24] Written in Blood: Kissing Disease miRNAs Could Predict Outcome of Patients With Chronic Lymphocytic Leukaemia
Lawrie, Charles H.
EBIOMEDICINE, 2015, 2 (06): : 489 - +
[25] Abnormal serum free light chain ratios are associated with poor survival in patients with chronic lymphocytic leukaemia
Pratt, G.
Harding, S.
Holder, R.
Fegan, C.
Pepper, C.
Oscier, D.
Mead, G.
BRITISH JOURNAL OF HAEMATOLOGY, 2008, 141 : 29 - 29
[26] A fatal case of postinfantile giant cell hepatitis in a patient with chronic lymphocytic leukaemia
Alexopoulou, A
Deutsch, M
Ageletopoulou, J
Delladetsima, JK
Marinos, E
Kapranos, N
Dourakis, SP
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 2003, 15 (05) : 551 - 555
[27] Abnormal serum free light chain ratios are associated with poor survival in patients with chronic lymphocytic leukaemia
Mead, G.
Harding, S.
Holder, R.
Fegan, C.
Pepper, C.
Oscier, D.
Pratt, G.
ANNALS OF ONCOLOGY, 2008, 19 : 90 - 90
[28] Linear IgA disease in association with chronic lymphocytic leukaemia
Usmani, N
Baxter, KF
Child, JA
Sheehan-Dare, R
BRITISH JOURNAL OF DERMATOLOGY, 2004, 151 (03) : 710 - 711
[29] Minimal residual disease assessment in chronic lymphocytic leukaemia
Sayala, Hazem A.
Rawstron, Andy C.
Hillmen, Peter
BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY, 2007, 20 (03) : 499 - 512
[30] The detection of TP53 mutations in chronic lymphocytic leukemia independently predicts rapid disease progression and is highly correlated with a complex aberrant karyotype
Dicker, F.
Herholz, H.
Schnittger, S.
Nakao, A.
Patten, N.
Wu, L.
Kern, W.
Haferlach, T.
Haferlach, C.
LEUKEMIA, 2009, 23 (01) : 117 - 124

← 1 2 3 4 5 →