Sulfur dioxide prodrugs: triggered release of SO2 via a click reaction

被引:60
|
作者
Wang, Wenyi
Ji, Xingyue [1 ]
Du, Zhenming
Wang, Binghe [1 ]
机构
[1] Georgia State Univ, Dept Chem, Atlanta, GA 30303 USA
基金
美国国家卫生研究院;
关键词
HYDROGEN-SULFIDE; 1,1-DIOXIDE; DERIVATIVES; BISULFITE; CYSTEINE; SYSTEMS; DONORS; PROBES; CELLS; THIOL;
D O I
10.1039/c6cc08844a
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Sulfur dioxide (SO2) is being recognized as a possible endogenous gasotransmitter with importance on par with that of NO, CO, and H2S. Herein we describe a series of SO2 prodrugs that are activated for SO2 release via a bioorthogonal click reaction. The release rate can be tuned by adjusting the substituents on the prodrug.
引用
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页码:1370 / 1373
页数:4
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