Sulfur dioxide prodrugs: triggered release of SO2 via a click reaction

被引：60
|
作者：
Wang, Wenyi
Ji, Xingyue [1 ]
Du, Zhenming
Wang, Binghe [1 ]
机构：
[1] Georgia State Univ, Dept Chem, Atlanta, GA 30303 USA
来源：
CHEMICAL COMMUNICATIONS | 2017年 / 53卷 / 08期
基金：
美国国家卫生研究院;
关键词：
HYDROGEN-SULFIDE; 1,1-DIOXIDE; DERIVATIVES; BISULFITE; CYSTEINE; SYSTEMS; DONORS; PROBES; CELLS; THIOL;
D O I：
10.1039/c6cc08844a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Sulfur dioxide (SO2) is being recognized as a possible endogenous gasotransmitter with importance on par with that of NO, CO, and H2S. Herein we describe a series of SO2 prodrugs that are activated for SO2 release via a bioorthogonal click reaction. The release rate can be tuned by adjusting the substituents on the prodrug.
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页码：1370 / 1373
页数：4
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