The Aneuploidy Paradox in Cell Growth and Tumorigenesis

被引：77
|
作者：
Weaver, Beth A. [1 ]
Cleveland, Don W. [2 ,3 ]
机构：
[1] Univ Wisconsin, Dept Pharmacol, Madison, WI 53706 USA
[2] Univ Calif San Diego, Ludwig Inst Canc Res, Dept Cellular & Mol Med, La Jolla, CA 92093 USA
[3] Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA
来源：
CANCER CELL | 2008年 / 14卷 / 06期
关键词：
D O I：
10.1016/j.ccr.2008.11.011
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Aneuploidy, an abnormal chromosome number, is a frequent characteristic of malignant cells, leading to the suggestion that aneuploidy drives tumorigenesis. In a recent issue of Science, Williams et al. identified a paradoxical relationship between aneuploidy and its linkage to tumorigenesis: chromosome gains in nontransformed cells are antiproliferative, despite frequently occurring in human tumors.
引用
收藏
页码：431 / 433
页数：3
相关论文
共 50 条
  • [41] Not just for housekeeping: protein initiation and elongation factors in cell growth and tumorigenesis
    Thornton, S
    Anand, N
    Purcell, D
    Lee, J
    JOURNAL OF MOLECULAR MEDICINE-JMM, 2003, 81 (09): : 536 - 548
  • [42] Nuclear PI3K signaling in cell growth and tumorigenesis
    Davis, William J.
    Lehmann, Peter Z.
    Li, Weimin
    FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2015, 3
  • [43] Crosstalk Between ROS and Autophagy in Tumorigenesis: Understanding the Multifaceted Paradox
    Hasan, Adria
    Rizvi, Suroor Fatima
    Parveen, Sana
    Pathak, Neelam
    Nazir, Aamir
    Mir, Snober S.
    FRONTIERS IN ONCOLOGY, 2022, 12
  • [44] The ATM-p53 pathway suppresses aneuploidy-induced tumorigenesis
    Li, Min
    Fang, Xiao
    Baker, Darren J.
    Guo, Linjie
    Gao, Xue
    Wei, Zhubo
    Han, Shuhua
    van Deursen, Jan M.
    Zhang, Pumin
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (32) : 14188 - 14193
  • [45] USP44 regulates centrosome positioning to prevent aneuploidy and suppress tumorigenesis
    Zhang, Ying
    Foreman, Oded
    Wigle, Dennis A.
    Kosari, Farhad
    Vasmatzis, George
    Salisbury, Jeffrey L.
    van Deursen, Jan
    Galardy, Paul J.
    JOURNAL OF CLINICAL INVESTIGATION, 2012, 122 (12): : 4362 - 4374
  • [46] Too much and never enough: Synthetic excess and metabolic inefficiency of aneuploidy in tumorigenesis
    Watson, Emma V.
    FASEB JOURNAL, 2022, 36
  • [47] Cell biology - Aneuploidy and cancer
    Pellman, David
    NATURE, 2007, 446 (7131) : 38 - 39
  • [48] The Paradox of Oestradiol-Induced Breast Cancer Cell Growth and Apoptosis
    Maximov, Philipp Y.
    Lewis-Wambi, Joan S.
    Jordan, Virgil Craig
    CURRENT SIGNAL TRANSDUCTION THERAPY, 2009, 4 (02) : 88 - 102
  • [49] The Eurasian growth paradox
    Aslund, Anders
    Jenish, Nazgul
    ANNUAL WORLD BANK CONFERENCE ON DEVELOPMENT ECONOMICS-REGIONAL 2007: BEYOND TRANSITION, 2007, : 25 - +
  • [50] Aneuploidy as a promoter and suppressor of malignant growth
    Anand Vasudevan
    Klaske M. Schukken
    Erin L. Sausville
    Vishruth Girish
    Oluwadamilare A. Adebambo
    Jason M. Sheltzer
    Nature Reviews Cancer, 2021, 21 : 89 - 103
12345