The Aneuploidy Paradox in Cell Growth and Tumorigenesis

被引：77
|
作者：
Weaver, Beth A. [1 ]
Cleveland, Don W. [2 ,3 ]
机构：
[1] Univ Wisconsin, Dept Pharmacol, Madison, WI 53706 USA
[2] Univ Calif San Diego, Ludwig Inst Canc Res, Dept Cellular & Mol Med, La Jolla, CA 92093 USA
[3] Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA
来源：
CANCER CELL | 2008年 / 14卷 / 06期
关键词：
D O I：
10.1016/j.ccr.2008.11.011
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Aneuploidy, an abnormal chromosome number, is a frequent characteristic of malignant cells, leading to the suggestion that aneuploidy drives tumorigenesis. In a recent issue of Science, Williams et al. identified a paradoxical relationship between aneuploidy and its linkage to tumorigenesis: chromosome gains in nontransformed cells are antiproliferative, despite frequently occurring in human tumors.
引用
收藏
页码：431 / 433
页数：3
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