The Aneuploidy Paradox in Cell Growth and Tumorigenesis

被引：77
|
作者：
Weaver, Beth A. [1 ]
Cleveland, Don W. [2 ,3 ]
机构：
[1] Univ Wisconsin, Dept Pharmacol, Madison, WI 53706 USA
[2] Univ Calif San Diego, Ludwig Inst Canc Res, Dept Cellular & Mol Med, La Jolla, CA 92093 USA
[3] Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA
来源：
CANCER CELL | 2008年 / 14卷 / 06期
关键词：
D O I：
10.1016/j.ccr.2008.11.011
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Aneuploidy, an abnormal chromosome number, is a frequent characteristic of malignant cells, leading to the suggestion that aneuploidy drives tumorigenesis. In a recent issue of Science, Williams et al. identified a paradoxical relationship between aneuploidy and its linkage to tumorigenesis: chromosome gains in nontransformed cells are antiproliferative, despite frequently occurring in human tumors.
引用
收藏
页码：431 / 433
页数：3
相关论文
共 50 条
  • [21] AMNIOTIC-FLUID CELL-GROWTH AND FETAL ANEUPLOIDY
    ELEJALDE, BR
    DEELEJALDE, MM
    SOTO, A
    LANCET, 1995, 345 (8954): : 924 - 925
  • [22] Ing1b in cell growth and tumorigenesis
    Coles, Andrew
    Liang, Huiling
    Zhu, Zhiqing
    Gallant, Judith
    Jones, Stephen
    CANCER RESEARCH, 2006, 66 (08)
  • [23] The ING Gene Family in the Regulation of Cell Growth and Tumorigenesis
    Coles, Andrew H.
    Jones, Stephen N.
    JOURNAL OF CELLULAR PHYSIOLOGY, 2009, 218 (01) : 45 - 57
  • [24] The role of primary cilia in cell growth, differentiation and tumorigenesis
    Inagaki, Masaki
    Kasahara, Kousuke
    Yamakawa, Daishi
    Matsuda, Chise
    Watanabe, Masatoshi
    CANCER SCIENCE, 2021, 112 : 1003 - 1003
  • [25] Negative feedbacks in normal cell growth and their suppression in tumorigenesis
    van Staveren, W. C. G.
    Detours, V.
    Dumont, J. E.
    Maenhaut, C.
    CELL CYCLE, 2006, 5 (06) : 571 - 572
  • [26] Hippo pathway in cell growth, organ size, and tumorigenesis
    Moroishi, T.
    Guan, K.
    MOLECULAR BIOLOGY OF THE CELL, 2016, 27
  • [27] Testing the 100 year old hypothesis that aneuploidy drives tumorigenesis
    Weaver, BA
    Silk, AD
    Putkey, FR
    Cleveland, DW
    MOLECULAR BIOLOGY OF THE CELL, 2004, 15 : 379A - 380A
  • [28] Mad2 overexpression promotes aneuploidy and tumorigenesis in mice
    Sotillo, Rocio
    Hernando, Eva
    Diaz-Rodriguez, Elena
    Teruya-Feldstein, Julie
    Cordon-Cardo, Carlos
    Lowe, Scott W.
    Benezra, Robert
    CANCER CELL, 2007, 11 (01) : 9 - 23
  • [29] Inorganic phosphate is a mitogen that alters cell growth, transformation and tumorigenesis
    Beck, George
    Camalier, Corinne
    Young, Matthew
    Yi, Ming
    Hood, Brian
    Perella, Christine
    Bobe, Gerd
    Stephens, Robert
    Conrads, Thomas
    Colburn, Nancy
    CANCER RESEARCH, 2009, 69
  • [30] Tissue growth and tumorigenesis in Drosophila: cell polarity and the Hippo pathway
    Richardson, Helena E.
    Portela, Marta
    CURRENT OPINION IN CELL BIOLOGY, 2017, 48 : 1 - 9
12345