Synthesis and biological evaluation of new nucleosides derived from trifluoromethoxy-4-quinolones

被引：16

作者：

Plevova, Kristina ^{[1
]}

Briestenska, Katarina ^{[2
]}

Colobert, Francoise ^{[3
]}

Mistrikova, Jela ^{[2
]}

Milata, Viktor ^{[1
]}

Leroux, Frederic R. ^{[4
]}

机构：

[1] Slovak Univ Technol Bratislava, Fac Chem & Food Technol, Inst Organ Chem Catalysis & Petrochem, Dept Organ Chem, Bratislava 81237, Slovakia

[2] Comenius Univ, Fac Nat Sci, Dept Microbiol & Virol, Bratislava 84215, Slovakia

[3] Univ Strasbourg ECPM, CNRS, UMR 7509, SynCat, F-67087 Strasbourg 02, France

[4] Univ Strasbourg ECPM, CNRS, UMR 7509, COHA Lab, F-67087 Strasbourg 02, France

来源：

TETRAHEDRON LETTERS | 2015年 / 56卷 / 36期

关键词：

Trifluoromethoxy-quinolone; Enolethers; Vorbruggen reaction; Gammaherpesvirus; Gould-Jacobs reaction; DERIVATIVES; ACID;

D O I：

10.1016/j.tetlet.2015.07.031

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of new nucleoside derivatives from 6- and 7-trifluoromethoxy-4-quinolones is described. The present synthesis is a combination of the Gould-Jacobs reaction for the preparation of 4-quinolones and a modified Vorbruggen reaction for the construction of nucleoside derivatives. The target compounds were tested against murine gammaherpesvirus MHV-68 type. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：5112 / 5115

页数：4

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