Synthesis and biological evaluation of novel 2′-deoxy-4′-thioimidazole nucleosides

被引：26
|
作者：
Wang, Y
Inguaggiato, G
Jasamai, M
Shah, M
Hughes, D
Slater, M
Simons, C
机构：
[1] Univ Wales Coll Cardiff, Welsh Sch Pharm, Cardiff CF1 3XF, S Glam, Wales
[2] Univ Wales Coll Cardiff, Dept Chem, Cardiff CF1 3TB, S Glam, Wales
[3] Glaxo Wellcome Res & Dev Ltd, Med Res Ctr, Stevenage SG1 2NY, Herts, England
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 1999年 / 7卷 / 03期
关键词：
D O I：
10.1016/S0968-0896(98)00255-7
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A study on the use of 3'-directing groups for the synthesis of imidazole 2'-deoxy-4'-thionucleosides led to varying alpha:beta ratios in the glycosylation reaction. The par a-nitrobenzoyl group gave the optimum result in the glycosylation step; therefore, this protected thiosugar 10b was used for the synthesis of a series of novel 2'-deoxy-4'-thio-imidazole nucleosides which have been evaluated for antiviral activity in vitro. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：481 / 487
页数：7
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