Synthesis and biological evaluation of novel 2′-deoxy-4′-thioimidazole nucleosides

被引：26

作者：

Wang, Y

Inguaggiato, G

Jasamai, M

Shah, M

Hughes, D

Slater, M

Simons, C

机构：

[1] Univ Wales Coll Cardiff, Welsh Sch Pharm, Cardiff CF1 3XF, S Glam, Wales

[2] Univ Wales Coll Cardiff, Dept Chem, Cardiff CF1 3TB, S Glam, Wales

[3] Glaxo Wellcome Res & Dev Ltd, Med Res Ctr, Stevenage SG1 2NY, Herts, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 1999年 / 7卷 / 03期

关键词：

D O I：

10.1016/S0968-0896(98)00255-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A study on the use of 3'-directing groups for the synthesis of imidazole 2'-deoxy-4'-thionucleosides led to varying alpha:beta ratios in the glycosylation reaction. The par a-nitrobenzoyl group gave the optimum result in the glycosylation step; therefore, this protected thiosugar 10b was used for the synthesis of a series of novel 2'-deoxy-4'-thio-imidazole nucleosides which have been evaluated for antiviral activity in vitro. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：481 / 487

页数：7

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