Synthesis and anti-herpes virus activity of 2'-deoxy-4'-thiopyrimidine nucleosides

被引：96

作者：

Rahim, SG ^{[1
]}

Trivedi, N ^{[1
]}

BogunovicBatchelor, MV ^{[1
]}

Hardy, GW ^{[1
]}

Mills, G ^{[1
]}

Selway, JWT ^{[1
]}

Snowden, W ^{[1
]}

Littler, E ^{[1
]}

Coe, PL ^{[1
]}

Basnak, I ^{[1
]}

Whale, RF ^{[1
]}

Walker, RT ^{[1
]}

机构：

[1] UNIV BIRMINGHAM,SCH CHEM,BIRMINGHAM B15 2TT,W MIDLANDS,ENGLAND

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1996年 / 39卷 / 03期

关键词：

D O I：

10.1021/jm950029r

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 5-substituted 2'-deoxy-4'-thiopyrimidine nucleosides was synthesized and evaluated as potential antiviral agents. A number of analogues such as 2'-deoxy-5-propyl-4'-thiouridine (3ii), 2'-deoxy-5-isopropyl-4'-thiouridine (3iii), 5-cyclopropyl-2'-deoxy-4'-thiouridine (3iv), 2'-deoxy-4'-thio-5-vinyluridine (3viii), and 5-(2-chloroethyl)-2'-deoxy-4'-thiouridin (3xx) were found to be highly active against herpes simplex virus type-1 (HSV-1) and varicella tester virus (VZV) in vitro with no significant cytotoxicity. The compound with the broadest spectrum of activity was 2'-deoxy-5-ethyl-4'-thiouridine (3i) which showed significant activity against HSV-1, HSV-2, and VZV.

引用

页码：789 / 795

页数：7

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