Synthesis and biological evaluation of new nucleosides derived from trifluoromethoxy-4-quinolones

被引：16
|
作者：
Plevova, Kristina [1 ]
Briestenska, Katarina [2 ]
Colobert, Francoise [3 ]
Mistrikova, Jela [2 ]
Milata, Viktor [1 ]
Leroux, Frederic R. [4 ]
机构：
[1] Slovak Univ Technol Bratislava, Fac Chem & Food Technol, Inst Organ Chem Catalysis & Petrochem, Dept Organ Chem, Bratislava 81237, Slovakia
[2] Comenius Univ, Fac Nat Sci, Dept Microbiol & Virol, Bratislava 84215, Slovakia
[3] Univ Strasbourg ECPM, CNRS, UMR 7509, SynCat, F-67087 Strasbourg 02, France
[4] Univ Strasbourg ECPM, CNRS, UMR 7509, COHA Lab, F-67087 Strasbourg 02, France
来源：
TETRAHEDRON LETTERS | 2015年 / 56卷 / 36期
关键词：
Trifluoromethoxy-quinolone; Enolethers; Vorbruggen reaction; Gammaherpesvirus; Gould-Jacobs reaction; DERIVATIVES; ACID;
D O I：
10.1016/j.tetlet.2015.07.031
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The synthesis of new nucleoside derivatives from 6- and 7-trifluoromethoxy-4-quinolones is described. The present synthesis is a combination of the Gould-Jacobs reaction for the preparation of 4-quinolones and a modified Vorbruggen reaction for the construction of nucleoside derivatives. The target compounds were tested against murine gammaherpesvirus MHV-68 type. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5112 / 5115
页数：4
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