Two-photon excited peptide nanodrugs for precise photodynamic therapy

被引：12

作者：

Cao, Hongqian ^{[1
,2
]}

Qi, Yanfei ^{[3
]}

Gao, Xibao ^{[1
]}

Zi Jin Wei ^{[2
]}

Xia, Jiarui ^{[1
]}

Wang, Lei ^{[2
]}

Wang, Hao ^{[2
]}

Yang, Yang ^{[2
]}

Li, Junbai ^{[4
]}

机构：

[1] Shandong Univ, Sch Publ Hlth, Jinan, Shandong, Peoples R China

[2] Natl Ctr Nanosci & Technol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing, Peoples R China

[3] Jilin Univ, Sch Publ Hlth, Changchun, Jilin, Peoples R China

[4] Chinese Acad Sci, Inst Chem, CAS Key Lab Colloid Interface & Chem Thermodynam, Beijing, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2021年 / 57卷 / 18期

基金：

中国国家自然科学基金; 国家重点研发计划;

关键词：

Functional motifs - Nanodrugs - Novel peptides - Photodynamic therapy (PDT) - Tumor targets - Two photon imaging - Two-photon excited;

D O I：

10.1039/d0cc08219h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel peptide nanodrug composed of three functional motifs, bis(pyrene), FFVLK and CREKA, was used as a two-photon excited photosensitizer for precise photodynamic therapy (PDT). The system presented excellent two-photon imaging ability, tumor target effect and high reactive oxygen species productivity for improving treatment precision and efficiency in PDT.

引用

页码：2245 / 2248

页数：4

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