Biocompatible conjugated fluorenylporphyrins for two-photon photodynamic therapy and fluorescence imaging

被引：23
|
作者：
Shi, Limiao [1 ]
Nguyen, Christophe [2 ]
Daurat, Morgane [2 ,3 ]
Dhieb, Abdelhamid Chiheb [1 ,4 ]
Smirani, Wajda [4 ]
Blanchard-Desce, Mireille [5 ]
Gary-Bobo, Magali [2 ]
Mongin, Olivier [1 ]
Paul-Roth, Christine [1 ]
Paul, Frederic [1 ]
机构：
[1] Univ Rennes, INSA Rennes, CNRS, ISCR,UMR 6226, F-35000 Rennes, France
[2] Univ Montpellier, Inst Biomol Max Mousseron, UMR 5247, 15 Ave Charles Flahault, F-34093 Montpellier 05, France
[3] NanoMedSyn, 15 Ave Charles Flahault, F-34093 Montpellier 05, France
[4] Univ Carthage, Fac Sci Bizerte, Lab Chim Mat, Zarzouna 7021, Tunisia
[5] Univ Bordeaux, Inst Sci Mol, CNRS, UMR 5255, F-33405 Talence, France
来源：
CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 81期
关键词：
SINGLET-OXYGEN GENERATION; CORED DERIVATIVES; CROSS-SECTION; ABSORPTION; PHOTOSENSITIZERS; ENHANCEMENT; SENSITIZERS; PORPHYRINS; EXCITATION; DENDRIMERS;
D O I：
10.1039/c9cc05657b
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The photophysical properties of a new series of fluorenyl porphyrins bearing water-solubilising oligoethyleneglycol chains are described. These biocompatible compounds present very good two-photon absorption and singlet oxygen generation properties, while retaining some fluorescence in water. After testing in vitro on breast cancer cells, some of them were shown to be efficient non-toxic two-photon photosensitisers allowing for fluorescence imaging, thus demonstrating their theranostic potential.
引用
收藏
页码：12231 / 12234
页数：4
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