Two-photon excited peptide nanodrugs for precise photodynamic therapy

被引：12
|
作者：
Cao, Hongqian [1 ,2 ]
Qi, Yanfei [3 ]
Gao, Xibao [1 ]
Zi Jin Wei [2 ]
Xia, Jiarui [1 ]
Wang, Lei [2 ]
Wang, Hao [2 ]
Yang, Yang [2 ]
Li, Junbai [4 ]
机构：
[1] Shandong Univ, Sch Publ Hlth, Jinan, Shandong, Peoples R China
[2] Natl Ctr Nanosci & Technol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing, Peoples R China
[3] Jilin Univ, Sch Publ Hlth, Changchun, Jilin, Peoples R China
[4] Chinese Acad Sci, Inst Chem, CAS Key Lab Colloid Interface & Chem Thermodynam, Beijing, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2021年 / 57卷 / 18期
基金：
中国国家自然科学基金; 国家重点研发计划;
关键词：
Functional motifs - Nanodrugs - Novel peptides - Photodynamic therapy (PDT) - Tumor targets - Two photon imaging - Two-photon excited;
D O I：
10.1039/d0cc08219h
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A novel peptide nanodrug composed of three functional motifs, bis(pyrene), FFVLK and CREKA, was used as a two-photon excited photosensitizer for precise photodynamic therapy (PDT). The system presented excellent two-photon imaging ability, tumor target effect and high reactive oxygen species productivity for improving treatment precision and efficiency in PDT.
引用
收藏
页码：2245 / 2248
页数：4
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